{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:26:06Z","timestamp":1787099166955,"version":"build-2736575974"},"reference-count":65,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Thalassaemia is a hereditary haemoglobinopathy characterised by impaired globin synthesis, resulting in ineffective erythropoiesis and systemic iron overload. While current management relies on blood transfusions and chelation, these often fail to address the underlying molecular signalling dysregulation that contributes to the disease's progression, such as the imbalance in erythropoietin production and the activation of inflammatory pathways. Brazilin, the primary homoisoflavonoid from\n                    <jats:italic>Biancaea sappan<\/jats:italic>\n                    L., presents a multifaceted therapeutic profile. This review synthesises evidence of brazilin's activity as a potent iron chelator and reactive oxygen species (ROS) scavenger and anti\u2010inflammatory agent, while evaluating its potential as a novel JAK2 inhibitor. Molecular docking suggests brazilin may bind to the JAK2 ATP\u2010binding pocket, though functional validation is still required. By modulating the erythroferrone (ERFE)\u2013hepcidin (HAMP) axis, brazilin potentially restores iron homeostasis and mitigates splenomegaly. We further evaluate its pharmacokinetics and safety profile, highlighting low toxicity and high oral bioavailability. This positions brazilin as a promising lead candidate for thalassaemia adjunct treatment, warranting further in\u00a0vivo validation.\n                  <\/jats:p>","DOI":"10.1111\/1440-1681.70145","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T02:09:09Z","timestamp":1786414149000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brazilin From\n                    <i>Biancaea sappan<\/i>\n                    as a Multi\u2010Target Candidate in Thalassaemia: Mechanistic Insights Into Iron Chelation, Antioxidant Activity, and Potential\n                    <scp>JAK2<\/scp>\n                    Modulation"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7822-2717","authenticated-orcid":false,"given":"Racy","family":"Youngest","sequence":"first","affiliation":[{"name":"Biotechnology Doctoral Program Universitas Padjadjaran  Bandung Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusof","family":"Kamisah","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Universiti Kebangsaan Malaysia  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratu","family":"Safitri","sequence":"additional","affiliation":[{"name":"Department of Biology Universitas Padjadjaran  Sumedang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ani Melani","family":"Maskoen","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Universitas Jenderal Achmad Yani  Cimahi Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"issue":"10","key":"e_1_2_12_2_1","first-page":"1","article-title":"Improving Ineffective Erythropoiesis in Thalassemia: A Hope on the Horizon","volume":"13","author":"Madan U.","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22137229"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000002046"},{"issue":"1","key":"e_1_2_12_5_1","first-page":"189","article-title":"Activation of STAT and SMAD Signaling Induces Hepcidin Re\u2010Expression as a Therapeutic Target for \u03b2\u2010Thalassemia Patients","volume":"10","author":"Saad H. 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