{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:25:48Z","timestamp":1787099148159,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274063"],"award-info":[{"award-number":["82274063"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["xzy012024155"],"award-info":[{"award-number":["xzy012024155"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2026,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Food allergy (FA) is a disorder marked by a significant incidence of detrimental immunological responses to certain dietary constituents, while preventive measures and regulatory treatments are scarce. Mast cells (MCs) are integral to the pathogenesis of FA mediated by Immunoglobulin E (IgE). The activation of MCs is modulated by their intracellular Ca\n 2+<\/jats:sup>\n concentrations, with Ca\n V<\/jats:sub>\n 1.2 serving as a voltage\u2010gated calcium channel that regulates calcium influx in MCs.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n The aim of this study was to examine the influence of Ca\n V<\/jats:sub>\n 1.2 on MCs' activation and its role in the onset and progression of FA.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The inhibitory effect of nimodipine (Nim) on MCs activation in\u00a0vitro was evaluated by detecting LAD2 degranulation and cytokine release; the anti\u2010food allergy effect of Nim was examined by the establishment of an IgE\u2010mediated FA model; the effect of Ca\n V<\/jats:sub>\n 1.2 on the occurrence of FA was investigated using conditional knockout of Ca\n V<\/jats:sub>\n 1.2 in MCs (CKO) mice.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Nim inhibited MCs activation in\u00a0vitro and alleviated ovalbumin (OVA)\u2010induced FA in\u00a0vivo. The expression of Ca\n V<\/jats:sub>\n 1.2 in MCs exhibited detrimental effects, whereas its deficiency ameliorated local and systemic allergy and significantly alleviated FA in mice. When Ca\n V<\/jats:sub>\n 1.2 was replenished in CKO mice by BMMC injection, such supplementation exacerbated FA symptoms.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Depression of Ca\n V<\/jats:sub>\n 1.2 in MCs attenuates the activation of MCs and alleviates the symptoms of FA. These results suggest that Ca\n V<\/jats:sub>\n 1.2 could be a new target for FA.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1440-1681.70148","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T23:57:21Z","timestamp":1786579041000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["\n Ca\n V<\/sub>\n 1.2\n <\/scp>\n Is Implicated in IgE\u2010Mediated Mast Cell Activation and Food Allergy"],"prefix":"10.1111","volume":"53","author":[{"given":"Tingting","family":"Deng","sequence":"first","affiliation":[{"name":"School of Pharmacy Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Norinco General Hospital Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Meng","sequence":"additional","affiliation":[{"name":"School of 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