{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:04:53Z","timestamp":1789718693334,"version":"4.0.1"},"reference-count":64,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004772","name":"Natural Science Foundation of Ningxia Province","doi-asserted-by":"publisher","award":["2022AAC05053"],"award-info":[{"award-number":["2022AAC05053"]}],"id":[{"id":"10.13039\/501100004772","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Chronic renal failure (CRF) represents the advanced stage of chronic kidney disease, for which no specific pharmacological treatments are currently available. Traditional Chinese medicine has demonstrated notable efficacy in managing CRF. Shengqingjiangzhuo capsules (SQJZ capsules), a traditional Chinese medicinal formulation, are employed clinically in the treatment of CRF. However, the precise mechanisms underlying its therapeutic effects remain insufficiently understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The SQJZ capsule's chemical components were identified using UPLC\u2010Q\u2010Exactive\u2010Orbitrap\u2010MS. TGF\u03b21\u2010induced GECs and adenine\u2010induced CRF models in mice were developed. Exosome miRNA sequencing, quantitative polymerase chain reaction (qPCR), Western blot and dual\u2010luciferase reporter assays explored the interaction between miR\u201031\u20105p and HO\u20101, and their effects on ferroptosis markers (ROS, GSH, MDA, Fe\n                      <jats:sup>2+<\/jats:sup>\n                      , SLC7A11, GCLC), mitochondrial membrane potential and fibrosis markers \u03b1\u2010SMA and collagen I.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study is the first to employ UPLC\u2010Q\u2010Exactive\u2010Orbitrap\u2010MS technology to analyse SQJZ capsules, identifying 82 active components. It indicates that TGF\u2010\u03b21\u2010stimulated GECs\u2010derived exosomes increase miR\u201031\u20105p in TECs, causing HO\u20101 inhibition and ferroptosis. The active drug in SQJZ capsules serum counteracts these effects, suggesting anti\u2010ferroptosis and anti\u2010fibrosis properties and improving renal function in cell and CRF animal models. Overall, SQJZ capsules reduce renal fibrosis by modulating the miR\u201031\u20105p\/HO\u20101 axis and inhibiting ferroptosis in TECs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SQJZ capsules is associated with amelioration of renal fibrosis by suppressing GECs\u2010derived exosomal miR\u201031\u20105p, which derepresses HO\u20101 expression in TECs, thereby inhibiting ferroptosis and subsequent renal fibrosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1440-1681.70151","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:15:01Z","timestamp":1787890501000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Shengqingjiangzhuo Capsules Alleviates Renal Fibrosis by Targeting Glomerular Endothelial Cells Exosome\n                    <scp>miR<\/scp>\n                    \u201031\u20105p\/\n                    <scp>HO<\/scp>\n                    \u20101 to Suppress Tubular Epithelial Cells Ferroptosis"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2376-4359","authenticated-orcid":false,"given":"Feng","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Nephrology, Ningxia Hui Autonomous Region Hospital of Traditional Chinese Medicine Ningxia Hui Autonomous Region Academy of Traditional Chinese Medicine  Yinchuan Ningxia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Ningxia Hui Autonomous Region Hospital of Traditional Chinese Medicine Ningxia Hui Autonomous Region Academy of Traditional Chinese Medicine  Yinchuan Ningxia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaxi","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Ningxia Hui Autonomous Region Hospital of Traditional Chinese Medicine Ningxia Hui Autonomous Region Academy of Traditional Chinese Medicine  Yinchuan Ningxia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Ningxia Medical University  Yinchuan Ningxia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Ningxia Hui Autonomous Region Hospital of Traditional Chinese Medicine Ningxia Hui Autonomous Region Academy of Traditional Chinese Medicine  Yinchuan Ningxia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Li","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Ningxia Medical University  Yinchuan Ningxia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Ningxia Medical University  Yinchuan Ningxia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nephrology First Teaching Hospital of Tianjin University of Traditional Chinese Medicine  Tianjin China"},{"name":"National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion  Tianjin China"},{"name":"Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8284-8942","authenticated-orcid":false,"given":"Anrong","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Ningxia Hui Autonomous Region Hospital of Traditional Chinese Medicine Ningxia Hui Autonomous Region Academy of Traditional Chinese Medicine  Yinchuan Ningxia China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109429"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.3724\/abbs.2024049"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2020.06.023"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1134\/s0006297923100164"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.1973877"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12763"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.3791\/64147"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2024.01.001"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010018\u20101157\u2010x"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.23529"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882\u2010018\u20100982\u20106"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118812"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073792"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12203"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau6977"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.448"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.16288\/j.yczz.20\u2010112"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.11.006"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242115520"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901599RR"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20081977"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.62478"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.131102"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901599RR"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010408"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21186547"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401\u2010023\u201001140\u20104"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.675617"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2022.01.006"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010020\u20102298\u20102"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001336\u20104"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.4149\/gpb_2022061"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11040589"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12122728"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.778998"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2022.01.003"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2018_2658"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010015\u20100830\u20101"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117189"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2025.108750"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2020.07.007"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/0886022x.2025.2539936"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.13913\/j.cnki.41\u20101110\/r.2016.02.013"},{"issue":"6","key":"e_1_2_14_45_1","first-page":"503","article-title":"Experimental Study on the Protective Mechanism of Shengqingjiangzhuo Capsules on Chronic Renal Failure Rats [in Chinese]","volume":"19","author":"Yang Y.","year":"2018","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine on Nephrology"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2024.2336128"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2018.1535750"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20100716\u20103995\u20105_17"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15041123"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20100716\u20102728\u20100_32"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13567\u2010023\u201001186\u20106"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e25131"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14101"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418\u2010019\u20100349\u2010y"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes13122201"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2012101031"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1242\/bio.015990"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210\u2010025\u201004681\u2010z"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010020\u201003362\u20104"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156762"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1737751"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.181032"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2025.04.047"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2025.05.423"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.Epi\u201010\u20100071"}],"container-title":["Clinical and Experimental Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1440-1681.70151","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1440-1681.70151","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1440-1681.70151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:01:13Z","timestamp":1789718473000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1440-1681.70151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":64,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/1440-1681.70151"],"URL":"https:\/\/doi.org\/10.1111\/1440-1681.70151","archive":["Portico"],"relation":{},"ISSN":["0305-1870","1440-1681"],"issn-type":[{"value":"0305-1870","type":"print"},{"value":"1440-1681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,27]]},"assertion":[{"value":"2026-05-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70151"}}