{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T02:31:28Z","timestamp":1774492288589,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T00:00:00Z","timestamp":1393891200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"State Health and Research Advisory Council (SHRAC) Research Translation Project","award":["RSD-02720"],"award-info":[{"award-number":["RSD-02720"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Lang &amp; Comm Disor"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Very early aphasia rehabilitation studies have shown mixed results. Differences in therapy intensity and therapy type contribute significantly to the equivocal results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare a standardized, prescribed very early aphasia therapy regimen with a historical usual care control group at therapy completion (4\u20135 weeks post\u2010stroke) and again at follow\u2010up (6 months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods &amp; Procedures<\/jats:title><jats:p>This study compared two cohorts from successive studies conducted in four Australian acute\/sub\u2010acute hospitals. The studies had near identical recruitment, blinded assessment and data\u2010collection protocols. The Very Early Rehabilitation (VER) cohort (<jats:italic>N<\/jats:italic> = 20) had mild\u2013severe aphasia and received up to 20 1\u2010h sessions of impairment\u2010based aphasia therapy, up to 5 weeks. The control cohort (<jats:italic>n<\/jats:italic> = 27) also had mild\u2013severe aphasia and received usual care (UC) therapy for up to 4 weeks post\u2010stroke. The primary outcome measure was the Aphasia Quotient (AQ) and a measure of communicative efficiency (DA) at therapy completion. Outcomes were measured at baseline, therapy completion and 6 months post\u2010stroke and were compared using Generalised Estimating Equations (GEE) models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcomes &amp; Results<\/jats:title><jats:p>After controlling for initial aphasia and stroke disability, the GEE models demonstrated that at the primary end\u2010point participants receiving VER achieved 18% greater recovery on the AQ and 1.5% higher DA scores than those in the control cohort. At 6 months, the VER participants maintained a 16% advantage in recovery on the AQ and 0.6% more on DA scores over the control cohort participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Implications<\/jats:title><jats:p>A prescribed, impairment\u2010based aphasia therapy regimen, provided daily in very early post\u2010stroke recovery, resulted in significantly greater communication gains in people with mild\u2013severe aphasia at completion of therapy and at 6 months, when compared with a historical control cohort. Further research is required to demonstrate large\u2010scale and long\u2010term efficacy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1460-6984.12074","type":"journal-article","created":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T11:45:05Z","timestamp":1393933505000},"page":"149-161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["A comparison of aphasia therapy outcomes before and after a Very Early Rehabilitation programme following stroke"],"prefix":"10.1111","volume":"49","author":[{"given":"Erin","family":"Godecke","sequence":"first","affiliation":[{"name":"Faculty of Health, Engineering and Science Edith Cowan University  Joondalup WA Australia"},{"name":"Clinical Centre of Research Excellence in Aphasia Rehabilitation  Brisbane QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie A.","family":"Ciccone","sequence":"additional","affiliation":[{"name":"Faculty of Health, Engineering and Science Edith Cowan University  Joondalup WA Australia"},{"name":"Clinical Centre of Research Excellence in Aphasia Rehabilitation  Brisbane QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew S.","family":"Granger","sequence":"additional","affiliation":[{"name":"Osborne Park Hospital North Metropolitan Health Service  Osborne Park WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tapan","family":"Rai","sequence":"additional","affiliation":[{"name":"School of Mathematical Sciences University of Technology Sydney  Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"West","sequence":"additional","affiliation":[{"name":"Osborne Park Hospital North Metropolitan Health Service  Osborne Park WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Cream","sequence":"additional","affiliation":[{"name":"Osborne Park Hospital North Metropolitan Health Service  Osborne Park WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jade","family":"Cartwright","sequence":"additional","affiliation":[{"name":"School of Psychology and Speech Pathology Curtin University and Curtin Health Innovation Research Institute  Bentley WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme J.","family":"Hankey","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacology University of Western Australia; Department of Neurology Sir Charles Gairdner Hospital  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215507078486"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1094428104263672"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)93206-O"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.201"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000062343.64383.D0"},{"key":"e_1_2_8_7_1","volume-title":"Amsterdam\u2013Nijmegen Test Voor Alledaagse Taalvaardigheden Lisse","author":"Blomert L.","year":"1995"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e4407"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta16260"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1044\/1058-0360.0404.94"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000425.pub3"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1310\/tsr1504-325"},{"key":"e_1_2_8_13_1","volume-title":"Adult Aphasia Rehabilitation: Applied Pragmatics","author":"Davis G. 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