{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:29:10Z","timestamp":1791293350404,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,1,16]],"date-time":"2014-01-16T00:00:00Z","timestamp":1389830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"BMBF","award":["0315832A, 0315832B, 01KI1009A"],"award-info":[{"award-number":["0315832A, 0315832B, 01KI1009A"]}]}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Microbiology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"Summary<\/jats:title>\n \n The anterior nares are an important reservoir for opportunistic pathogens and commensal microorganisms. A barcoded\n I<\/jats:styled-content>\n llumina paired\u2010end sequencing method targeting the 16\n S<\/jats:styled-content>\n ribosomal\n RNA V<\/jats:styled-content>\n 1\u20102 hypervariable region was developed to compare the bacterial diversity of the anterior nares across distinct human populations (volunteers from\n G<\/jats:styled-content>\n ermany vs a\n B<\/jats:styled-content>\n abongo\n P<\/jats:styled-content>\n ygmy tribe,\n A<\/jats:styled-content>\n frica). Of the 251 phylotypes detected, 231 could be classified to the genus level and 109 to the species level, including the unambiguous identification of the ubiquitous\n \n S<\/jats:italic>\n <\/jats:styled-content>\n taphylococcus aureus<\/jats:italic>\n and\n \n M<\/jats:italic>\n <\/jats:styled-content>\n oraxella catarrhalis<\/jats:italic>\n . The global bacterial community of both adult populations revealed that they shared 85% of the phylotypes, suggesting that our global bacterial communities have likely been with us for thousands of years. Of the 34 phylotypes unique to the non\u2010westernized population, most were related to members within the suborder\n \n M<\/jats:italic>\n <\/jats:styled-content>\n icrococcineae<\/jats:italic>\n . There was an even more overwelming distinction between children and adults of the same population, suggesting a progression of a childhood community of high\u2010diversity comprising species of\n \n M<\/jats:italic>\n <\/jats:styled-content>\n oraxellaceae<\/jats:italic>\n and\n \n S<\/jats:italic>\n <\/jats:styled-content>\n treptococcaceae<\/jats:italic>\n to an adult community of lower diversity comprising species of\n \n P<\/jats:italic>\n <\/jats:styled-content>\n ropionibacteriaceae<\/jats:italic>\n ,\n \n C<\/jats:italic>\n <\/jats:styled-content>\n lostridiales<\/jats:italic>\n \u2005\n I<\/jats:styled-content>\n ncertae\n S<\/jats:styled-content>\n edis\n XI<\/jats:styled-content>\n ,\n \n C<\/jats:italic>\n <\/jats:styled-content>\n orynebacteriaceae<\/jats:italic>\n and\n \n S<\/jats:italic>\n <\/jats:styled-content>\n taphylococcaceae<\/jats:italic>\n . Thus, age was a stronger factor for accounting for differing bacterial assemblages than the origin of the human population sampled.\n <\/jats:p>","DOI":"10.1111\/1462-2920.12362","type":"journal-article","created":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T07:23:39Z","timestamp":1387437819000},"page":"2939-2952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":180,"title":["Comparing the anterior nare bacterial community of two discrete human populations using\n I<\/scp>\n llumina amplicon sequencing"],"prefix":"10.1111","volume":"16","author":[{"given":"Am\u00e9lia","family":"Camarinha\u2010Silva","sequence":"first","affiliation":[{"name":"Microbial Interactions and Processes Research Group Helmholtz Centre for Infection Research Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruy","family":"J\u00e1uregui","sequence":"additional","affiliation":[{"name":"Microbial Interactions and Processes Research Group Helmholtz Centre for Infection Research Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Chaves\u2010Moreno","sequence":"additional","affiliation":[{"name":"Microbial Interactions and Processes Research Group Helmholtz Centre for Infection Research Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.A.","family":"Oxley","sequence":"additional","affiliation":[{"name":"Microbial Interactions and Processes Research Group Helmholtz Centre for Infection Research Braunschweig Germany"},{"name":"Infection Immunology Research Group Helmholtz Centre for Infection Research Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frieder","family":"Schaumburg","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology University Hospital M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Becker","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology University Hospital M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa L.","family":"Wos\u2010Oxley","sequence":"additional","affiliation":[{"name":"Microbial Interactions and Processes Research Group Helmholtz Centre for Infection Research Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar H.","family":"Pieper","sequence":"additional","affiliation":[{"name":"Microbial Interactions and Processes Research Group Helmholtz Centre for Infection Research Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/599119"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1007028107"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017035"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2276"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2307\/1942268"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6941.2011.01197.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2012.8"},{"key":"e_1_2_6_9_1","first-page":"265","article-title":"Nonparametric estimation of the number of classes in a population","volume":"11","author":"Chao A.","year":"1984","journal-title":"Scand J Statist"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531532"},{"key":"e_1_2_6_11_1","volume-title":"Change in Marine Communities: an Approach to Statistical Analysis and Interpretation","author":"Clarke K.R.","year":"2001"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.12.1584"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1177486"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2011.74"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq461"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.71.9.5642-5645.2005"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006216"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2012.152"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010598"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171700"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0010005"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1184"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2307\/1934145"},{"key":"e_1_2_6_24_1","first-page":"21","volume-title":"Evolution of Protein Molecules. 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