{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:52:30Z","timestamp":1792165950159,"version":"4.4.0"},"reference-count":146,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T00:00:00Z","timestamp":1399248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Microbiology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    In natural habitats, bacteria often occur in multicellular communities characterized by a robust extracellular matrix of proteins, amyloid fibres, exopolysaccharides and extracellular\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    . These biofilms show pronounced stress resistance including a resilience against antibiotics that causes serious medical and technical problems. This review summarizes recent studies that have revealed clear spatial physiological differentiation, complex supracellular architecture and striking morphology in macrocolony biofilms. By responding to gradients of nutrients, oxygen, waste products and signalling compounds that build up in growing biofilms, various stress responses determine whether bacteria grow and proliferate or whether they enter into stationary phase and use their remaining resources for maintenance and survival. As a consequence, biofilms differentiate into at least two distinct layers of vegetatively growing and stationary phase cells that exhibit very different cellular physiology. This includes a stratification of matrix production with a major impact on microscopic architecture, biophysical properties and directly visible morphology of macrocolony biofilms. Using\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>E<\/jats:italic>\n                    <\/jats:styled-content>\n                    <jats:italic>scherichia coli<\/jats:italic>\n                    as a model system, this review also describes our detailed current knowledge about the underlying molecular control networks \u2013 prominently featuring sigma factors, transcriptional cascades and second messengers \u2013 that drive this spatial differentiation and points out directions for future research.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.12483","type":"journal-article","created":{"date-parts":[[2014,4,13]],"date-time":"2014-04-13T22:52:50Z","timestamp":1397429570000},"page":"1455-1471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":208,"title":["Stress responses go three dimensional \u2013 the spatial order of physiological differentiation in bacterial macrocolony biofilms"],"prefix":"10.1111","volume":"16","author":[{"given":"Diego O.","family":"Serra","sequence":"first","affiliation":[{"name":"Institute of Biology\/Microbiology Humboldt Universit\u00e4t zu Berlin  Chausseestr. 117 Berlin 10115 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regine","family":"Hengge","sequence":"additional","affiliation":[{"name":"Institute of Biology\/Microbiology Humboldt Universit\u00e4t zu Berlin  Chausseestr. 117 Berlin 10115 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-46-2-175"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600668"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.175.19.6238-6244.1993"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2007.05.011"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.4.1251-1256.2003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1311642110"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05770.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2004.05.001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2004.11.008"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03865.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00981-06"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2013.06.002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.018"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46064-0"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/mr.56.1.100-122.1992"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M314145200"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-101011-155705"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.191384198"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.26306-0"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.188.6.2027-2037.2006"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2001.02529.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.06040.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1887"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.64.4.694-708.2000"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(99)10004-1"},{"key":"e_1_2_8_27_1","first-page":"249","article-title":"Untersuchungen \u00fcber Bakterien IV: Beitr\u00e4ge zur Biologie der Bacillen","volume":"7","author":"Cohn F.","year":"1876","journal-title":"Beitr Biol Pflanzen"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2011.02657.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.41.100187.002251"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5418.1318"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.188.8.3073-3087.2006"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/1758-2229.12085"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1218703110"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.02273-12"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2006.01143.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05249.x"},{"key":"e_1_2_8_37_1","article-title":"Curli biogenesis: order out of disorder","author":"Evans M.L.","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2010.07179.x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-2920.2001.00238.x"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2005.04649.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.hdy.6801077"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1340"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2415"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01569-06"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.188.3.1049-1059.2006"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03877.x"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.188.6.2233-2243.2006"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2003.08.005"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0030154"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1218898110"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.4.2659-2665.2001"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.091208.073349"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506687102"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600828103"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2004.11.004"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00239-13"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2009.08.014"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2109"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1128\/9781555816667.ch16"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1128\/9781555816841.ch15"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1479050505001699"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2009.12.011"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408507102"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.54.1.499"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.40.110405.090423"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.9.4953"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.12.3768-3776.1999"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.227902"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2012.07976.x"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.6.2038-2049.2005"},{"key":"e_1_2_8_71_1","first-page":"1","volume-title":"Bacterial Regulatory Networks","author":"Klauck E.","year":"2011"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.4147"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.215244.113"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.2093"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.41.110306.130400"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1991.tb01825.x"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.14.4474-4481.1991"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.177.16.4676-4680.1995"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2007.01418.x"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2009.06939.x"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.120"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.96.188101"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M414050200"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.176.23.7345-7351.1994"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1813709"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2009.06882.x"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403064101"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2011.00322.x"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0505350102"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.353705"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14034560"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2012.08002.x"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.62.12.4632-4640.1996"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1211037"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04342.x"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2010.02112.x"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.039131-0"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01468-10"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00223-11"},{"key":"e_1_2_8_100_1"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.03.001"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks055"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.475808"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00497-13"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.01061.x"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1128\/9781555816841.ch17"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1996.tb02491.x"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2002.03123.x"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12066"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00107-07"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.20053"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910560107"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/325279a0"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-4557-x"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.00791.x"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.01822.x"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2005.04697.x"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00043-12"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03432.x"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2203"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00946-13"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00103-13"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020081"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04206.x"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.024257-0"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.24.7500-7508.1999"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2010.03.020"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1838"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.56.012302.160705"},{"key":"e_1_2_8_130_1","volume-title":"Bacterial Stress Responses","author":"Storz G.","year":"2011"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2012.07965.x"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2010.07498.x"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1217178110"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601629"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.188.8.3099-3109.2006"},{"key":"e_1_2_8_136_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1645008"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2960"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2005.11.020"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.5.1591-1603.2005"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05440.x"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.70.10.6188-6196.2004"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00022-12"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-005-0263-8"},{"key":"e_1_2_8_144_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2011.02503.x"},{"key":"e_1_2_8_145_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.7.4028"},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm456"},{"key":"e_1_2_8_147_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2001.02337.x"}],"container-title":["Environmental Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1462-2920.12483","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1462-2920.12483","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1462-2920.12483","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/sfamjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1462-2920.12483","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T05:15:52Z","timestamp":1761887752000},"score":1,"resource":{"primary":{"URL":"https:\/\/sfamjournals.onlinelibrary.wiley.com\/doi\/10.1111\/1462-2920.12483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,5]]},"references-count":146,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/1462-2920.12483"],"URL":"https:\/\/doi.org\/10.1111\/1462-2920.12483","archive":["Portico"],"relation":{},"ISSN":["1462-2912","1462-2920"],"issn-type":[{"value":"1462-2912","type":"print"},{"value":"1462-2920","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,5]]},"assertion":[{"value":"2014-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-05-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}