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The first step in\n                    <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>\n                    biosynthesis is the conversion of farnesyl diphosphate to trichodiene (\n                    <jats:styled-content style=\"fixed-case\">TD<\/jats:styled-content>\n                    ), a volatile organic compound (\n                    <jats:styled-content style=\"fixed-case\">VOC<\/jats:styled-content>\n                    ), catalysed by a sesquiterpene synthase encoded by the\n                    <jats:italic>tri5<\/jats:italic>\n                    gene. Expression of\n                    <jats:italic>tri5<\/jats:italic>\n                    in the biocontrol strain\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>T<\/jats:italic>\n                    <\/jats:styled-content>\n                    <jats:italic>richoderma harzianum<\/jats:italic>\n                    \u2005\n                    <jats:styled-content style=\"fixed-case\">CECT<\/jats:styled-content>\n                    2413 resulted in production of\n                    <jats:styled-content style=\"fixed-case\">TD<\/jats:styled-content>\n                    in parallel with a reduction of ergosterol biosynthesis and an unexpected increase in the level of squalene. Transformants expressing\n                    <jats:italic>tri5<\/jats:italic>\n                    displayed low chitinase activity and induced expression of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>B<\/jats:italic>\n                    <\/jats:styled-content>\n                    <jats:italic>otrytis cinerea<\/jats:italic>\n                    \u2005\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>BOT<\/jats:italic>\n                    <\/jats:styled-content>\n                    genes, although their total antagonistic potential against phytopathogenic fungi was not reduced.\n                    <jats:styled-content style=\"fixed-case\">VOCs<\/jats:styled-content>\n                    released by the\n                    <jats:italic>tri5<\/jats:italic>\n                    \u2010transformant induced expression of tomato defence genes related to salicylic acid (\n                    <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>\n                    ), and\n                    <jats:styled-content style=\"fixed-case\">TD<\/jats:styled-content>\n                    itself strongly induced the expression of\n                    <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>\n                    \u2010responsive genes and reduced the development of lateral roots. Together, these results suggest that\n                    <jats:styled-content style=\"fixed-case\">TD<\/jats:styled-content>\n                    acts as a signalling\n                    <jats:styled-content style=\"fixed-case\">VOC<\/jats:styled-content>\n                    in the interactions of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>T<\/jats:italic>\n                    <\/jats:styled-content>\n                    <jats:italic>richoderma<\/jats:italic>\n                    with plants and other microorganisms by modulating the perception of this fungus to a given environment. Moreover, the\n                    <jats:styled-content style=\"fixed-case\">TD<\/jats:styled-content>\n                    ability to induce systemic defences indicates that complex trichothecene structures may not be necessary for inducing such responses.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.12506","type":"journal-article","created":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T07:39:01Z","timestamp":1399880341000},"page":"2628-2646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Production of trichodiene by\n                    <scp>\n                      <i>T<\/i>\n                    <\/scp>\n                    <i>richoderma harzianum<\/i>\n                    alters the perception of this biocontrol strain by plants and antagonized fungi"],"prefix":"10.1111","volume":"17","author":[{"given":"M\u00f3nica G.","family":"Malmierca","sequence":"first","affiliation":[{"name":"Area of Microbiology Universitary School of Agricultural Engineers University of Le\u00f3n  Campus de Ponferrada, Avda. 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Astorga s\/n Ponferrada 24400 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy J.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Bacterial Foodborne Pathogen and Mycology Unit National Center for Agricultural Utilization Research USDA\/ARS  Peoria IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Monte","sequence":"additional","affiliation":[{"name":"Spanish\u2013Portuguese Centre of Agricultural Research (CIALE) Department of Microbiology and Genetics University of Salamanca  Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Area of Microbiology Universitary School of Agricultural Engineers University of Le\u00f3n  Campus de Ponferrada, Avda. 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