{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T17:51:21Z","timestamp":1790531481908,"version":"4.1.0"},"reference-count":71,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T00:00:00Z","timestamp":1404777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Danish Council for Independent Research, Technology and Production Sciences (FTP)","award":["09-066098"],"award-info":[{"award-number":["09-066098"]}]}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Microbiology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"Summary<\/jats:title>\n \n \n L<\/jats:italic>\n <\/jats:styled-content>\n isteria monocytogenes<\/jats:italic>\n can cause the potentially fatal food\u2010borne disease listeriosis, and the use of bacteriocin\u2010producing lactic acid bacteria to control\n \n L<\/jats:italic>\n <\/jats:styled-content>\n . monocytogenes<\/jats:italic>\n holds great promise. However, the development of bacteriocin resistance is a potential challenge, and the purpose of this study was to determine if exposure to sublethal concentrations of pediocin\u2010containing\n \n L<\/jats:italic>\n <\/jats:styled-content>\n actobacillus plantarum<\/jats:italic>\n \u2005\n WHE<\/jats:styled-content>\n 92 supernatant could prime\n \n L<\/jats:italic>\n <\/jats:styled-content>\n . monocytogenes<\/jats:italic>\n for resistance. By transcriptomic analysis, we found two, 55 and 539 genes differentially expressed after 10, 60 and 180\u2009min of exposure to\n \n L<\/jats:italic>\n <\/jats:styled-content>\n . plantarum<\/jats:italic>\n \u2005\n WHE<\/jats:styled-content>\n 92 supernatant as compared with control exposures. We observed temporal expression changes in genes regulated by the two component system\n LisRK<\/jats:styled-content>\n and the alternative sigma factors\n SigB<\/jats:styled-content>\n and\n SigL<\/jats:styled-content>\n . Additionally, several genes involved in bacteriocin resistance were induced. \u0394\n \n lisR<\/jats:italic>\n <\/jats:styled-content>\n , \u0394\n \n sigB<\/jats:italic>\n <\/jats:styled-content>\n and \u0394\n \n sigL<\/jats:italic>\n <\/jats:styled-content>\n mutants were all more resistant than wild types to\n \n L<\/jats:italic>\n <\/jats:styled-content>\n . plantarum<\/jats:italic>\n \u2005\n WHE<\/jats:styled-content>\n 92 supernatant. Conclusively,\n LisRK<\/jats:styled-content>\n ,\n SigB<\/jats:styled-content>\n and\n SigL<\/jats:styled-content>\n regulation and genes associated with resistance are involved in the temporal adaptive response to pediocin, and all three regulatory systems affect pediocin resistance. Thus, a single exposure to a sublethal pediocin concentration initiates a response pointing to resistance, and indicates that further research exploring the link between adaptive responses and resistance is needed.\n <\/jats:p>","DOI":"10.1111\/1462-2920.12534","type":"journal-article","created":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T23:29:14Z","timestamp":1402529354000},"page":"1134-1151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["A single exposure to a sublethal pediocin concentration initiates a resistance\u2010associated temporal cell envelope and general stress response in\n \n L<\/i>\n <\/scp>\n isteria monocytogenes<\/i>"],"prefix":"10.1111","volume":"17","author":[{"given":"Martin F.","family":"Laursen","sequence":"first","affiliation":[{"name":"Department of Systems Biology Technical University of Denmark DK\u20102800 Kongens Lyngby Denmark"},{"name":"National Food Institute Technical 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