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More than 200\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>B<\/jats:italic>\n                    <\/jats:styled-content>\n                    <jats:italic>.\u2009cereus<\/jats:italic>\n                    group isolates have been sequenced. However, there are few reports of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>B<\/jats:italic>\n                    <\/jats:styled-content>\n                    <jats:italic>.\u2009cereus<\/jats:italic>\n                    group antibiotic resistance genes. This study identified two functional classes of macrolide phosphotransferases (\n                    <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\n                    phs) in the\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>B<\/jats:italic>\n                    <\/jats:styled-content>\n                    <jats:italic>.\u2009cereus<\/jats:italic>\n                    group.\n                    <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                    luster\n                    <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                    Mphs inactivate 14\u2010 and 15\u2010membered macrolides while\n                    <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                    luster\n                    <jats:styled-content style=\"fixed-case\">B M<\/jats:styled-content>\n                    phs inactivate 14\u2010, 15\u2010 and 16\u2010membered compounds. The genomic region surrounding the\n                    <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                    luster\n                    <jats:styled-content style=\"fixed-case\">B M<\/jats:styled-content>\n                    ph gene is related to various plasmid sequences, suggesting that this gene is an acquired resistance gene.\n                    <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\n                    n contrast, the\n                    <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                    luster\n                    <jats:styled-content style=\"fixed-case\">A M<\/jats:styled-content>\n                    ph gene is located in a chromosomal region conserved among all\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>B<\/jats:italic>\n                    <\/jats:styled-content>\n                    <jats:italic>.\u2009cereus<\/jats:italic>\n                    group isolates, and data indicated that it was acquired early in the evolution of the group. Therefore, the\n                    <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                    luster\n                    <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                    gene can be considered an intrinsic resistance gene. However, the gene itself is not present in all strains and our comparative genomics analyses showed that it is exchanged among strains of the\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>B<\/jats:italic>\n                    <\/jats:styled-content>\n                    <jats:italic>.\u2009cereus<\/jats:italic>\n                    group by the mean of homologous recombination. These results provide an alternative mechanism to intrinsic resistance.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.12578","type":"journal-article","created":{"date-parts":[[2014,7,25]],"date-time":"2014-07-25T06:21:19Z","timestamp":1406269279000},"page":"1560-1573","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Functional characterization and phylogenetic analysis of acquired and intrinsic macrolide phosphotransferases in the\n                    <scp>\n                      <i>B<\/i>\n                    <\/scp>\n                    <i>acillus cereus<\/i>\n                    group"],"prefix":"10.1111","volume":"17","author":[{"given":"Chao","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Microbial Resources Institute of Microbiology Chinese Academy of Sciences  Beijing 100101 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