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Co\u2010feeding transmission is a potential immune evasion strategy because the vector\u2010borne pathogen minimizes the time spent in the vertebrate host. We tested whether the Lyme disease pathogen,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>B<\/jats:italic>\n                    <\/jats:styled-content>\n                    <jats:italic>orrelia afzelii<\/jats:italic>\n                    , can use co\u2010feeding transmission to escape the acquired immune response in the vertebrate host. We induced a strain\u2010specific, protective antibody response by immunizing mice with one of two variants of\n                    <jats:styled-content style=\"fixed-case\">OspC<\/jats:styled-content>\n                    (A3 and A10), the highly variable outer surface protein\n                    <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                    of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>B<\/jats:italic>\n                    <\/jats:styled-content>\n                    <jats:italic>orrelia<\/jats:italic>\n                    pathogens. Immunized mice were challenged via tick bite with\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>B<\/jats:italic>\n                    <\/jats:styled-content>\n                    <jats:italic>.\u2009afzelii<\/jats:italic>\n                    strains A3 or A10 and infested with larval ticks at days 2 and 34 post\u2010infection to measure co\u2010feeding and systemic transmission respectively. Antibodies against a particular\n                    <jats:styled-content style=\"fixed-case\">OspC<\/jats:styled-content>\n                    variant significantly reduced co\u2010feeding transmission of the targeted (homologous) strain but not the non\u2010targeted (heterologous) strain. Cross\u2010immunity between\n                    <jats:styled-content style=\"fixed-case\">OspC<\/jats:styled-content>\n                    antigens had no effect in co\u2010feeding ticks but reduced the spirochaete load twofold in ticks infected via systemic transmission. In summary,\n                    <jats:styled-content style=\"fixed-case\">OspC<\/jats:styled-content>\n                    \u2010specific antibodies reduced co\u2010feeding transmission of a homologous but not a heterologous strain of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>B<\/jats:italic>\n                    <\/jats:styled-content>\n                    <jats:italic>.\u2009afzelii<\/jats:italic>\n                    . Co\u2010feeding transmission allowed\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>B<\/jats:italic>\n                    <\/jats:styled-content>\n                    <jats:italic>.\u2009afzelii<\/jats:italic>\n                    to evade the negative consequences of cross\u2010immunity on the tick spirochaete load.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.13065","type":"journal-article","created":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T02:43:31Z","timestamp":1443408211000},"page":"833-845","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Strain\u2010specific antibodies reduce co\u2010feeding transmission of the Lyme disease pathogen,\n                    <scp>\n                      <i>B<\/i>\n                    <\/scp>\n                    <i>orrelia afzelii<\/i>"],"prefix":"10.1111","volume":"18","author":[{"given":"Maxime","family":"Jacquet","sequence":"first","affiliation":[{"name":"Laboratory of Ecology and Evolution of Parasites Institute of Biology University of Neuch\u00e2tel  Emile Argand 11 2000 Neuch\u00e2tel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Durand","sequence":"additional","affiliation":[{"name":"Laboratory of Ecology and Evolution of Parasites Institute of Biology University of Neuch\u00e2tel  Emile Argand 11 2000 Neuch\u00e2tel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Rais","sequence":"additional","affiliation":[{"name":"Laboratory of Ecology and Evolution of Parasites Institute of Biology University of Neuch\u00e2tel  Emile Argand 11 2000 Neuch\u00e2tel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten 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