{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:44:37Z","timestamp":1793317477756,"version":"4.5.0"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T00:00:00Z","timestamp":1453334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scottish Government Food Land and People programme","id":[{"id":"https:\/\/ror.org\/04v2xmd71","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Wellcome Trust","award":["098051"],"award-info":[{"award-number":["098051"]}],"id":[{"id":"https:\/\/ror.org\/029chgv08","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Microbiology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Cereal fibres such as wheat bran are considered to offer human health benefits via their impact on the intestinal microbiota. We show here by 16S\n                    <jats:styled-content style=\"fixed-case\">rRNA<\/jats:styled-content>\n                    gene\u2010based community analysis that providing amylase\u2010pretreated wheat bran as the sole added energy source to human intestinal microbial communities in anaerobic fermentors leads to the selective and progressive enrichment of a small number of bacterial species. In particular,\n                    <jats:styled-content style=\"fixed-case\">OTUs<\/jats:styled-content>\n                    corresponding to uncultured\n                    <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\n                    achnospiraceae (\n                    <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>\n                    irmicutes) related to\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>E<\/jats:italic>\n                    <\/jats:styled-content>\n                    <jats:italic>ubacterium xylanophilum<\/jats:italic>\n                    and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>B<\/jats:italic>\n                    <\/jats:styled-content>\n                    <jats:italic>utyrivibrio<\/jats:italic>\n                    spp. were strongly enriched (by five to 160 fold) over 48 h in four independent experiments performed with different faecal inocula, while nine other Firmicutes\n                    <jats:styled-content style=\"fixed-case\">OTUs<\/jats:styled-content>\n                    showed &gt;\u20095\u2010fold enrichment in at least one experiment. Ferulic acid was released from the wheat bran during degradation but was rapidly converted to phenylpropionic acid derivatives via hydrogenation, demethylation and dehydroxylation to give metabolites that are detected in human faecal samples. Pure culture work using bacterial isolates related to the enriched\n                    <jats:styled-content style=\"fixed-case\">OTUs<\/jats:styled-content>\n                    , including several butyrate\u2010producers, demonstrated that the strains caused substrate weight loss and released ferulic acid, but with limited further conversion. We conclude that breakdown of wheat bran involves specialist primary degraders while the conversion of released ferulic acid is likely to involve a multi\u2010species pathway.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.13158","type":"journal-article","created":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T08:43:42Z","timestamp":1449218622000},"page":"2214-2225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":159,"title":["Wheat bran promotes enrichment within the human colonic microbiota of butyrate\u2010producing bacteria that release ferulic acid"],"prefix":"10.1111","volume":"18","author":[{"given":"Sylvia H.","family":"Duncan","sequence":"first","affiliation":[{"name":"Rowett Institute of Nutrition and Health University of Aberdeen  Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy R.","family":"Russell","sequence":"additional","affiliation":[{"name":"Rowett Institute of Nutrition and Health University of Aberdeen  Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Quartieri","sequence":"additional","affiliation":[{"name":"Department of Life Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maddalena","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Life Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Parkhill","sequence":"additional","affiliation":[{"name":"Pathogen Genomics Group Wellcome Trust Sanger Institute  Hinxton Cambridgeshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5099-8495","authenticated-orcid":false,"given":"Alan W.","family":"Walker","sequence":"additional","affiliation":[{"name":"Rowett Institute of Nutrition and Health University of 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