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To this end, we selected a strain from the main zoonotic clonal\u2010complex, obtained a mutant in the ferric\u2010uptake\u2010regulator (Fur), and analyzed their transcriptomic profiles in both iron\u2010excess and iron\u2010poor conditions by using a strain\u2010specific microarray platform. Among the genes differentially expressed, we identified around 250 as putatively involved in virulence and survival\u2010related mechanisms. Then, we designed and performed a series of\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    tests to find out if the processes highlighted by the microarray experiments were in fact under iron and\/or Fur control. Our results support the hypothesis that iron acts as a niche marker, not always through Fur, for\n                    <jats:italic>V.\u00a0vulnificu<\/jats:italic>\n                    s controlling its entire life cycle. This ranges from survival in the marine environment, including motility and chemotaxis, to survival in the blood of their hosts, including host\u2010specific mechanisms of resistance to innate immunity. These mechanisms allow the bacterium to multiply and persist inside and between their hosts.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.13424","type":"journal-article","created":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T14:22:38Z","timestamp":1467037358000},"page":"4005-4022","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Iron and Fur in the life cycle of the zoonotic pathogen\n                    <i>Vibrio vulnificus<\/i>"],"prefix":"10.1111","volume":"18","author":[{"given":"David","family":"Pajuelo","sequence":"first","affiliation":[{"name":"Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED) University of Valencia Dr. Moliner, 50 Valencia 46100 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Hern\u00e1ndez\u2010Cabanyero","sequence":"additional","affiliation":[{"name":"Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED) University of Valencia Dr. Moliner, 50 Valencia 46100 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Sanjuan","sequence":"additional","affiliation":[{"name":"Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED) University of Valencia Dr. Moliner, 50 Valencia 46100 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung\u2010Te","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Institute of Basic Medical Sciences Tainan Taiwan Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Xavier","family":"Silva\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED) University of Valencia Dr. Moliner, 50 Valencia 46100 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