{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:00:20Z","timestamp":1788436820974,"version":"build-2803163510"},"reference-count":82,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T00:00:00Z","timestamp":1484697600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Microbiology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Chronic rhinosinusitis (CRS) is a common, debilitating condition characterized by long\u2010term inflammation of the nasal cavity and paranasal sinuses. The role of the sinonasal bacteria in CRS is unclear. We conducted a meta\u2010analysis combining and reanalysing published bacterial 16S rRNA sequence data to explore differences in sinonasal bacterial community composition and predicted function between healthy and CRS affected subjects. The results identify the most abundant bacteria across all subjects as\n                    <jats:italic>Staphylococcus<\/jats:italic>\n                    ,\n                    <jats:italic>Propionibacterium<\/jats:italic>\n                    ,\n                    <jats:italic>Corynebacterium<\/jats:italic>\n                    ,\n                    <jats:italic>Streptococcus<\/jats:italic>\n                    and an unclassified lineage of\n                    <jats:italic>Actinobacteria<\/jats:italic>\n                    . The meta\u2010analysis results suggest that the bacterial community associated with CRS patients is dysbiotic and ecological networks fostering healthy communities are fragmented. Increased dispersion of bacterial communities, significantly lower bacterial diversity, and increased abundance of members of the genus\n                    <jats:italic>Corynebacterium<\/jats:italic>\n                    are associated with CRS. Increased relative abundance and diversity of other members belonging to the phylum\n                    <jats:italic>Actinobacteria<\/jats:italic>\n                    and members from the genera\n                    <jats:italic>Propionibacterium<\/jats:italic>\n                    differentiated healthy sinuses from those that were chronically inflamed. Removal of\n                    <jats:italic>Burkholderia<\/jats:italic>\n                    and\n                    <jats:italic>Propionibacterium<\/jats:italic>\n                    phylotypes from the healthy community dataset was correlated with a significant increase in network fragmentation. This meta\u2010analysis highlights the potential importance of the genera\n                    <jats:italic>Burkholderia<\/jats:italic>\n                    and\n                    <jats:italic>Propionibacterium<\/jats:italic>\n                    as gatekeepers, whose presence may be important in maintaining a stable sinonasal bacterial community.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.13632","type":"journal-article","created":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T14:37:39Z","timestamp":1480516659000},"page":"381-392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":170,"title":["Bacterial community collapse: a meta\u2010analysis of the sinonasal microbiota in chronic rhinosinusitis"],"prefix":"10.1111","volume":"19","author":[{"given":"Brett","family":"Wagner Mackenzie","sequence":"first","affiliation":[{"name":"School of Medicine, Department of Surgery The University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Waite","sequence":"additional","affiliation":[{"name":"Australian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences University of Queensland Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hoggard","sequence":"additional","affiliation":[{"name":"School of Biological Sciences The University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard G.","family":"Douglas","sequence":"additional","affiliation":[{"name":"School of Medicine, Department of Surgery The University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Taylor","sequence":"additional","affiliation":[{"name":"School of Biological Sciences The University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi","family":"Biswas","sequence":"additional","affiliation":[{"name":"School of Medicine, Department of Surgery The University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9993.2001.01070.pp.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003783"},{"key":"e_1_2_6_4_1","unstructured":"Auguie B.(2015). gridExtra: Miscellaneous functions for \u201cgrid\u201d graphics. 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