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These modules shed light on the interactions between RNAs, proteins and metabolites, revealing biological features of transcription and translation, cell wall biosynthesis, C1 metabolism and N metabolism. Network analysis identified four nodes that function as hubs and bottlenecks, namely, coenzyme A, HPr kinases, S\u2010adenosylmethionine and the ribonuclease P\u2010protein, suggesting pivotal roles for them in\n                    <jats:italic>Clostridium<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.13732","type":"journal-article","created":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T04:57:45Z","timestamp":1490072265000},"page":"2588-2603","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["The pangenome of the genus\n                    <scp>\n                      <i>C<\/i>\n                    <\/scp>\n                    <i>lostridium<\/i>"],"prefix":"10.1111","volume":"19","author":[{"given":"Zulema","family":"Udaondo","sequence":"first","affiliation":[{"name":"Calle Energ\u00eda Solar 1, Building D, Campus Palmas Altas Abengoa Research, Biotechnology 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