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Its gastric cavity can serve as a simple model of microbial\u2013animal digestive associations, yet poorly characterized. Using state\u2010of\u2010the\u2010art metagenomic population binning and catalyzed reporter deposition fluorescence\n                    <jats:italic>in situ<\/jats:italic>\n                    hybridization (CARD\u2010FISH), we show that only four novel clonal phylotypes were consistently associated with multiple jellyfish adults. Two affiliated close to\n                    <jats:italic>Spiroplasma<\/jats:italic>\n                    and\n                    <jats:italic>Mycoplasma<\/jats:italic>\n                    genera, one to chlamydial \u2018\n                    <jats:italic>Candidatus<\/jats:italic>\n                    Syngnamydia\u2019, and one to bacteroidetal\n                    <jats:italic>Tenacibaculum<\/jats:italic>\n                    , and were at least one order of magnitude more abundant than any other bacteria detected. Metabolic modelling predicted an aerobic heterotrophic lifestyle for the chlamydia, which were found intracellularly in\n                    <jats:italic>Onychodromopsis<\/jats:italic>\n                    \u2010like ciliates. The\n                    <jats:italic>Spiroplasma<\/jats:italic>\n                    \u2010like organism was predicted to be an anaerobic fermenter associated to some jellyfish cells, whereas the\n                    <jats:italic>Tenacibaculum<\/jats:italic>\n                    \u2010like as free\u2010living aerobic heterotroph, densely colonizing the mesogleal axis inside the gastric filaments. The association between the jellyfish and its reduced microbiome was close and temporally stable, and possibly related to food digestion and protection from pathogens. Based on the genomic and microscopic data, we propose three candidate taxa: \u2018\n                    <jats:italic>Candidatus<\/jats:italic>\n                    Syngnamydia medusae\u2019, \u2018\n                    <jats:italic>Candidatus<\/jats:italic>\n                    Medusoplasma mediterranei\u2019 and \u2018\n                    <jats:italic>Candidatus<\/jats:italic>\n                    Tenacibaculum medusae\u2019.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.13763","type":"journal-article","created":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T06:18:40Z","timestamp":1492409920000},"page":"3039-3058","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["The low diverse gastric microbiome of the jellyfish\n                    <i>Cotylorhiza tuberculata<\/i>\n                    is dominated by four novel taxa"],"prefix":"10.1111","volume":"19","author":[{"given":"Tomeu","family":"Viver","sequence":"first","affiliation":[{"name":"Mediterranean Institute for Advanced Studies (IMEDEA; CSIC\u2010UIB) Marine Microbiology Group Esporles E\u201007190 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis H.","family":"Orellana","sequence":"additional","affiliation":[{"name":"School of Civil and Environmental Engineering Georgia Institute of Technology 311 Ferst Dr. NW Atlanta GA 30332 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet K.","family":"Hatt","sequence":"additional","affiliation":[{"name":"School of Civil and Environmental Engineering Georgia Institute of Technology 311 Ferst Dr. NW Atlanta GA 30332 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Urdiain","sequence":"additional","affiliation":[{"name":"Mediterranean Institute for Advanced Studies (IMEDEA; CSIC\u2010UIB) Marine Microbiology Group Esporles E\u201007190 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Mediterranean Institute for Advanced Studies (IMEDEA; CSIC\u2010UIB) Marine Microbiology Group Esporles E\u201007190 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Richter","sequence":"additional","affiliation":[{"name":"Ribocon GmbH Bremen 28359 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefa","family":"Ant\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Physiology, Genetics and Microbiology, and Multidisciplinary Institute for Environmental Studies Ramon Margalef University of Alicante Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Avian","sequence":"additional","affiliation":[{"name":"Department of Life Science University of Trieste Via L. 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