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The rapid emergence of methicillin\u2010resistant\n                    <jats:italic>S. aureus<\/jats:italic>\n                    following the clinical introduction of this antimicrobial drug and reports of resistance to all currently used anti\u2010staphylococcal drugs has added to its formidable reputation.\n                    <jats:italic>S. aureus<\/jats:italic>\n                    survival on the\u00a0skin and\n                    <jats:italic>in vivo<\/jats:italic>\n                    virulence is underpinned by a remarkable environmental adaptability, made possible by highly orchestrated regulation of gene expression and a capacity to undertake genome remodelling. Depending on the ecological or infection niche, controlled expression of a variety of adhesins can be initiated to facilitate adherence to extracellular matrix proteins, survival against desiccation or biofilm accumulation on implanted medical devices and host tissue. These adherence mechanisms complement toxin and enzyme production, immune evasion strategies, and antibiotic resistance and tolerance to collectively thwart efforts to develop reliable antimicrobial drug regimens and an effective\n                    <jats:italic>S. aureus<\/jats:italic>\n                    vaccine.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.13833","type":"journal-article","created":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T23:58:02Z","timestamp":1497916682000},"page":"3823-3833","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["<i>Into the storm<\/i>\n                    : Chasing the opportunistic pathogen\n                    <i>Staphylococcus aureus<\/i>\n                    from skin colonisation to life\u2010threatening infections"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3866-7161","authenticated-orcid":false,"given":"James 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