{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:27:01Z","timestamp":1791246421878,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T00:00:00Z","timestamp":1502668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573306"],"award-info":[{"award-number":["81573306"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Microbiology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Chemically mediated interactions have been hypothesized to be essential for ecosystem functioning as co\u2010occurring organisms can influence the performance of each other by metabolic means. Here, we present a co\u2010culture device that allows co\u2010culturing of microorganisms that are physically separated but can exchange chemical signals and metabolites. This setup was adopted to perform investigations on the secondary metabolisms of both a fungal\u2013bacterial community and an actinomycetic\u2013actinomycetic community. This study employed a metabolomics approach integrating LC\u2010MS profiling, multivariate data analysis and molecular networking techniques. LC\u2010MS measurements revealed a pronounced influence of such chemical communication on the metabolic profiles of synthetic co\u2010culture communities with a group of molecules being induced or upregulated in co\u2010cultures. A novel antibiotic exhibiting antibiotic properties against\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    was unveiled in the fungal\u2013bacterial community. Besides, a further survey of the fungal\u2013bacterial cross\u2010talk indicated that the production of co\u2010culture\u2010induced diphenyl ethers by fungi might result from the fungal response against the secretion of surfactins by bacteria in the cross\u2010talk. This study demonstrated that the presented co\u2010culture device and the metabolomic routine would facilitate the investigation on chemically mediated interactions in nature as well as cryptic natural products discovery.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.13858","type":"journal-article","created":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T02:08:44Z","timestamp":1500257324000},"page":"3606-3618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Synthetic multispecies microbial communities reveals shifts in secondary metabolism and facilitates cryptic natural product discovery"],"prefix":"10.1111","volume":"19","author":[{"given":"Yutong","family":"Shi","sequence":"first","affiliation":[{"name":"Ocean College Zhejiang University Hangzhou 310058 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