{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:45:35Z","timestamp":1791917135716,"version":"4.3.4"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Microbiology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Vibrio vulnificus<\/jats:italic>\n                    is a Gram\u2010negative aquatic bacterium first isolated by the United States (US) Centers for Disease Control and Prevention (CDC) in 1964. This bacterium is part of the normal microbiota of estuarine waters and occurs in high numbers in molluscan shellfish around the world, particularly in warmer months. Infections in humans are derived from consumption of seafood produce and from water exposure.\n                    <jats:italic>Vibrio vulnificus<\/jats:italic>\n                    is a striking and enigmatic human pathogen, yet many aspects related to its biology, genomics, virulence capabilities and epidemiology remain elusive and poorly understood. This pathogen is responsible for over 95% of seafood\u2010related deaths in the United States, and carries the highest fatality rate of any food\u2010borne pathogen. Indeed, infections associated with this pathogen that progress to primary septicaemia have a similar case fatality rate to category BSL 3 and 4 pathogens, such as anthrax, bubonic plague, Ebola and Marburg fever. Interestingly,\n                    <jats:italic>V. vulnificus<\/jats:italic>\n                    infections disproportionately affect males (\u223c85% of cases) and older patients (&gt;\u00a040 years), especially those with underlying conditions such as liver diseases, diabetes and immune disorders. New insights from molecular studies and comparative genomic approaches have offered tantalising insights into this pathogen. A recent increase and geographical spread in reported infections, in particular wound cases, underlines the growing international importance of\n                    <jats:italic>V. vulnificus<\/jats:italic>\n                    , particularly in the context of coastal warming. We outline and explore here a range of current data gaps regarding this important pathogen, and provide some current thoughts on approaches to elucidate key aspects associated with this bacterium.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.13955","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T01:56:42Z","timestamp":1507859802000},"page":"423-430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":248,"title":["<i>Vibrio vulnificus<\/i>\n                    : new insights into a deadly opportunistic pathogen"],"prefix":"10.1111","volume":"20","author":[{"given":"Craig","family":"Baker\u2010Austin","sequence":"first","affiliation":[{"name":"Weymouth Laboratory Centre for Environment Fisheries and Aquaculture Science, Barrack Road, Weymouth Dorset DT4 8UB England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James 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