{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T11:45:21Z","timestamp":1792755921173,"version":"4.5.0"},"reference-count":75,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,15]],"date-time":"2017-12-15T00:00:00Z","timestamp":1513296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51508302"],"award-info":[{"award-number":["51508302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Microbiology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The human gut microbiota is an important reservoir of antibiotic resistance genes (ARGs). A metagenomic approach and network analysis were used to establish a comprehensive antibiotic resistome catalog and to obtain co\u2010occurrence patterns between ARGs and microbial taxa in fecal samples from 180 healthy individuals from 11 different countries. In total, 507 ARG subtypes belonging to 20 ARG types were detected with abundances ranging from 7.12 \u00d7 10\n                    <jats:sup>\u22127<\/jats:sup>\n                    to 2.72 \u00d7 10\n                    <jats:sup>\u22121<\/jats:sup>\n                    copy of ARG\/copy of 16S\u2010rRNA gene. Tetracycline, multidrug, macrolide\u2010lincosamide\u2010streptogramin, bacitracin, vancomycin, beta\u2010lactam and aminoglycoside resistance genes were the top seven most abundant ARG types. The multidrug ABC transporter,\n                    <jats:italic>aad<\/jats:italic>\n                    E,\n                    <jats:italic>bac<\/jats:italic>\n                    A,\n                    <jats:italic>acr<\/jats:italic>\n                    B,\n                    <jats:italic>tet<\/jats:italic>\n                    M,\n                    <jats:italic>tet<\/jats:italic>\n                    W,\n                    <jats:italic>van<\/jats:italic>\n                    R and\n                    <jats:italic>van<\/jats:italic>\n                    S were shared by all 180 individuals, suggesting their common occurrence in the human gut. Compared to populations from the other 10 countries, the Chinese population harboured the most abundant ARGs. Moreover, LEfSe analysis suggested that the MLS resistance type and its subtype \u2018\n                    <jats:italic>erm<\/jats:italic>\n                    F\u2019 were representative ARGs of the Chinese population. Antibiotic inactivation, antibiotic target alteration and antibiotic efflux were the dominant resistance mechanism categories in all populations. Procrustes analysis revealed that microbial phylogeny structured the antibiotic resistome. Co\u2010occurrence patterns obtained via network analysis implied that 12 species might be potential hosts of 58 ARG subtypes.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.14009","type":"journal-article","created":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T13:12:25Z","timestamp":1512133945000},"page":"355-368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":180,"title":["Antibiotic resistome in a large\u2010scale healthy human gut microbiota deciphered by metagenomic and network analyses"],"prefix":"10.1111","volume":"20","author":[{"given":"Jie","family":"Feng","sequence":"first","affiliation":[{"name":"Division of Energy &amp; Environment, Graduate School at Shenzhen Tsinghua University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Energy &amp; Environment, Graduate School at Shenzhen Tsinghua University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Environmental Biotechnology Laboratory, Department of Civil Engineering The University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[{"name":"South China Sea Resource Exploitation and Protection Collaborative Innovation Center, School of Marine Sciences Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George F.","family":"Wells","sequence":"additional","affiliation":[{"name":"Department of Civil and Environmental Engineering Northwestern University Evanston IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Environmental Biotechnology Laboratory, Department of Civil Engineering The University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Energy &amp; Environment, Graduate School at Shenzhen Tsinghua University  China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2312"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.7.10.986"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104816"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2006.02.006"},{"key":"e_1_2_6_6_1","first-page":"45","article-title":"The pathogenic role of bacteroides\u2010vulgatus in patients with ulcerative\u2010colitis","volume":"30","author":"Bamba T.","year":"1995","journal-title":"J Gastroenterol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2008.07.029"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1200515109"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1013699998"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0803.010192"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1500183"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw475"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/491711"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10388"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2012.07.004"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M401701200"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7528"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0404.980417"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00486-06"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1220761"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13377"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.155465.113"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201300143"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1319284111"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17907-0"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01310-13"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/b706075k"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61956-X"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.13370"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3151"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2010.09.004"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1264\/jsme2.ME14054"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12198"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.catena.2016.01.005"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70318-9"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq1019"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2015.59"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn656"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-016-1133-6"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.5b03522"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1159483"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00419-13"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078822"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-015-0090-9"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9452"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/dnares\/dsw002"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-016-0199-5"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature17672"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00346-09"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13568"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.04.055"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2015.148"},{"key":"e_1_2_6_54_1","first-page":"54","article-title":"Bacteroides ovatus as the predominant commensal intestinal microbe causing a systemic antibody response in inflammatory bowel disease","volume":"9","author":"Saitoh S.","year":"2002","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2004.07.004"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.6026\/97320630001005"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-6-r60"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2066"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2009.0916"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1176950"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.202604299"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.5b01012"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.03128-13"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.092152899"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.marpolbul.2014.01.049"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1177\/003335490512000211"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-090110-102830"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1614"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw136"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11053"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks261"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfca.2015.01.007"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20145645"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.5b00729"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8603-2-6"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1222743110"}],"container-title":["Environmental Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1462-2920.14009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1462-2920.14009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1462-2920.14009","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/sfamjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1462-2920.14009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T21:42:43Z","timestamp":1761860563000},"score":1,"resource":{"primary":{"URL":"https:\/\/sfamjournals.onlinelibrary.wiley.com\/doi\/10.1111\/1462-2920.14009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,15]]},"references-count":75,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/1462-2920.14009"],"URL":"https:\/\/doi.org\/10.1111\/1462-2920.14009","archive":["Portico"],"relation":{},"ISSN":["1462-2912","1462-2920"],"issn-type":[{"value":"1462-2912","type":"print"},{"value":"1462-2920","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,15]]},"assertion":[{"value":"2017-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}