{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:58:53Z","timestamp":1790747933543,"version":"4.1.0"},"reference-count":83,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","award":["55008726"],"award-info":[{"award-number":["55008726"]}],"id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["724630\u2010CholeraIndex"],"award-info":[{"award-number":["724630\u2010CholeraIndex"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["31003A 162551"],"award-info":[{"award-number":["31003A 162551"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Microbiology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Bacteria of the genus\n                    <jats:italic>Vibrio<\/jats:italic>\n                    are common members of aquatic environments where they compete with other prokaryotes and defend themselves against grazing predators. A macromolecular protein complex called the type VI secretion system (T6SS) is used for both purposes. Previous research showed that the sole T6SS of the human pathogen\n                    <jats:italic>V. cholerae<\/jats:italic>\n                    is induced by extracellular (chitin) or intracellular (low c\u2010di\u2010GMP levels) cues and that these cues lead to distinctive signalling pathways for which the proteins TfoX and TfoY serve as master regulators. In this study, we tested whether the TfoX\u2010 and TfoY\u2010mediated regulation of T6SS, concomitantly with natural competence or motility, was conserved in non\u2010cholera\n                    <jats:italic>Vibrio<\/jats:italic>\n                    species, and if so, how these regulators affected the production of individual T6SSs in double\u2010armed vibrios. We show that, alongside representative competence genes, TfoX regulates at least one T6SS in all tested\n                    <jats:italic>Vibrio<\/jats:italic>\n                    species. TfoY, on the other hand, fostered motility in all vibrios but had a more versatile T6SS response in that it did not foster T6SS\u2010mediated killing in all tested vibrios. Collectively, our data provide evidence that the TfoX\u2010 and TfoY\u2010mediated signalling pathways are mostly conserved in diverse\n                    <jats:italic>Vibrio<\/jats:italic>\n                    species and important for signal\u2010specific T6SS induction.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.14562","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T04:46:48Z","timestamp":1550119608000},"page":"2231-2247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Ecological implications of gene regulation by TfoX and TfoY among diverse\n                    <i>Vibrio<\/i>\n                    species"],"prefix":"10.1111","volume":"21","author":[{"given":"Lisa C.","family":"Metzger","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Microbiology, Global Health Institute, School of Life Sciences Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e9mie","family":"Matthey","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology, Global Health Institute, School of Life Sciences Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candice","family":"Stoudmann","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology, Global Health Institute, School of Life Sciences Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther J.","family":"Collas","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology, Global Health Institute, School of Life Sciences Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7024-1489","authenticated-orcid":false,"given":"Melanie","family":"Blokesch","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology, Global Health Institute, School of Life Sciences Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL)  Lausanne 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