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However, these environments also have bioavailable forms of phosphorus incorporated into dissolved organic matter (DOM) that microbes with the necessary transport and hydrolysis metabolic pathways can access to supplement their phosphorus requirements. In this study we evaluated how the environment shapes the abundance and taxonomic distribution of the bacterial carbon\u2013phosphorus (C\u2013P) lyase pathway, an enzyme complex evolved to extract phosphate from phosphonates. Phosphonates are organophosphorus compounds characterized by a highly stable C\u2013P bond and are enriched in marine DOM. Similar to other known bacterial adaptions to low phosphate environments, C\u2013P lyase was found to become more prevalent as phosphate concentrations decreased. C\u2013P lyase was particularly enriched in the Mediterranean Sea and North Atlantic Ocean, two regions that feature sustained periods of phosphate depletion. In these regions, C\u2013P lyase was prevalent in several lineages of\n                    <jats:italic>Alphaproteobacteria<\/jats:italic>\n                    (\n                    <jats:italic>Pelagibacter<\/jats:italic>\n                    , SAR116,\n                    <jats:italic>Roseobacter<\/jats:italic>\n                    and\n                    <jats:italic>Rhodospirillales<\/jats:italic>\n                    ),\n                    <jats:italic>Gammaproteobacteria,<\/jats:italic>\n                    and\n                    <jats:italic>Actinobacteria<\/jats:italic>\n                    . The global scope of this analysis supports previous studies that infer phosphonate catabolism via C\u2013P lyase is an important adaptive strategy implemented by bacteria to alleviate phosphate limitation and expands the known geographic extent and taxonomic affiliation of this metabolic pathway in the ocean.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.14628","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T20:15:42Z","timestamp":1555013742000},"page":"2402-2414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":125,"title":["Phosphate\u2010limited ocean regions select for bacterial populations enriched in the carbon\u2013phosphorus lyase pathway for phosphonate degradation"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4235-9962","authenticated-orcid":false,"given":"Oscar A.","family":"Sosa","sequence":"first","affiliation":[{"name":"Daniel K. 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