{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:54:09Z","timestamp":1790506449653,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001736","name":"German-Israeli Foundation for Scientific Research and Development","doi-asserted-by":"publisher","award":["I\u201041\u2010416.6\u20102017"],"award-info":[{"award-number":["I\u201041\u2010416.6\u20102017"]}],"id":[{"id":"10.13039\/501100001736","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["2616\/18"],"award-info":[{"award-number":["2616\/18"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Microbiology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Non\u2010typhoidal\n                    <jats:italic>Salmonella enterica<\/jats:italic>\n                    (NTS) are diverse and important bacterial pathogens consisting of more than 2600 different serovars, with varying host\u2010specificity. Here, we characterized the poultry\u2010associated serovars in Israel, analysed their resistome and illuminated the molecular mechanisms underlying common multidrug resistance (MDR) patterns. We show that at least four serovars including Infantis, Muenchen, Newport and Virchow present a strong epidemiological association between their temporal trends in poultry and humans. Worrisomely, 60% from all of the poultry isolates tested (\n                    <jats:italic>n<\/jats:italic>\n                    =\u2009188) were multidrug resistant, mediated by chromosomal SNPs and different mobile genetics elements. A novel streptomycin\u2010azithromycin resistance island and previously uncharacterized versions of the mobilized\n                    <jats:italic>Salmonella<\/jats:italic>\n                    genomic island 1 (SGI1) were identified and characterized in\n                    <jats:italic>S<\/jats:italic>\n                    . Blockley and\n                    <jats:italic>S<\/jats:italic>\n                    . Kentucky isolates respectively. Moreover, we demonstrate that the acquisition of SGI1 does not impose fitness cost during growth under nutrient\u2010limited conditions or in the context of\n                    <jats:italic>Salmonella<\/jats:italic>\n                    infection in the mouse model. Overall, our data emphasize the role of the poultry production as a pool of specific epidemic MDR strains and autonomous genetic elements, which confer resistance to heavy metals and medically relevant antibiotics. These are likely to disseminate to humans via the food chain and fuel the increasing global antibiotic resistance crisis.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.14858","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T18:24:25Z","timestamp":1573583065000},"page":"413-432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Emergence of new variants of antibiotic resistance genomic islands among multidrug\u2010resistant\n                    <i>Salmonella enterica<\/i>\n                    in poultry"],"prefix":"10.1111","volume":"22","author":[{"given":"Emiliano","family":"Cohen","sequence":"first","affiliation":[{"name":"The Infectious Diseases Research Laboratory Sheba Medical Center  Tel\u2010Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Davidovich","sequence":"additional","affiliation":[{"name":"Central Laboratories Ministry of Health  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assaf","family":"Rokney","sequence":"additional","affiliation":[{"name":"Central Laboratories Ministry of Health  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Valinsky","sequence":"additional","affiliation":[{"name":"Central Laboratories Ministry of Health  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galia","family":"Rahav","sequence":"additional","affiliation":[{"name":"The Infectious Diseases Research Laboratory Sheba Medical Center  Tel\u2010Hashomer Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2540-6790","authenticated-orcid":false,"given":"Ohad","family":"Gal\u2010Mor","sequence":"additional","affiliation":[{"name":"The Infectious Diseases Research Laboratory Sheba Medical Center  Tel\u2010Hashomer Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Clinical Microbiology and Immunology Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw415"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.12.004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01395-16"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.12351"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-9-75"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2013.04.002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/cmb.2012.0021"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.19.5725-5732.2001"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00044"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2007-00249"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.03219-14"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000296"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01514-06"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00169-19"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015302"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00525-08"},{"key":"e_1_2_6_19_1","first-page":"5182","article-title":"The European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2016","volume":"16","author":"EFSA","year":"2018","journal-title":"EFSA Journal"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00598-11"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01881"},{"key":"e_1_2_6_22_1","article-title":"Persistent infection and long\u2010term carriage of typhoidal and nontyphoidal Salmonellae","volume":"32","author":"Gal\u2010Mor O.","year":"2019","journal-title":"Clin Microbiol Rev"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00794.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1611.100100"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2011.0064"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.7.2753-2759.2005"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1204"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01310-13"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.10.122"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001923"},{"key":"e_1_2_6_31_1","first-page":"e000269","article-title":"Global phylogenomics of multidrug\u2010resistant Salmonella enterica serotype Kentucky ST198","volume":"5","author":"Hawkey J.","year":"2019","journal-title":"Microb Genom"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2016.1230088"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2014.07.004"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2016.2180"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.14202\/vetworld.2019.504-521"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1004"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1632870100"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-food-041715-033251"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00732-12"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir409"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00120-15"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01229-06"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plasmid.2018.09.001"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-018-8847-2"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2016.07.033"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2018.05.006"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw318"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1903.111866"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2017.2403"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.1.1.5"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2006.3.59"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1701.P11101"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv154"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2199-7-31"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.03.023"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps\/pew342"},{"key":"e_1_2_6_57_1","doi-asserted-by":"crossref","first-page":"OH\u20100020\u20102013","DOI":"10.1128\/microbiolspec.OH-0020-2013","article-title":"One health and food\u2010borne disease: Salmonella transmission between humans, animals, and plants","volume":"2","author":"Silva C.","year":"2014","journal-title":"Microbiol Spectr"},{"key":"e_1_2_6_58_1","unstructured":"USDA(2017). Cost estimates of foodborne illnesses. URLhttps:\/\/www.ers.usda.gov\/data-products\/cost-estimates-of-foodborne-illnesses.aspx"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1080\/02652030600699320"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1106.041231"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/eva.12202"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70703-0"},{"key":"e_1_2_6_63_1","unstructured":"WHO(2017). Global priority list of antibiotic\u2010resistant bacteria to guide research discovery and development of new antibiotics. URL WWW document."},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv383"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005595"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000132"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2017.07.027"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks261"}],"container-title":["Environmental Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1462-2920.14858","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1462-2920.14858","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/sfamjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1462-2920.14858","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:55:16Z","timestamp":1761893716000},"score":1,"resource":{"primary":{"URL":"https:\/\/sfamjournals.onlinelibrary.wiley.com\/doi\/10.1111\/1462-2920.14858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,25]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1111\/1462-2920.14858"],"URL":"https:\/\/doi.org\/10.1111\/1462-2920.14858","archive":["Portico"],"relation":{},"ISSN":["1462-2912","1462-2920"],"issn-type":[{"value":"1462-2912","type":"print"},{"value":"1462-2920","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,25]]},"assertion":[{"value":"2019-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}