{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:16:32Z","timestamp":1792084592135,"version":"4.4.0"},"reference-count":96,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T00:00:00Z","timestamp":1584057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Microbiology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The type VI secretion system (T6SS) is a proteinaceous weapon used by many Gram\u2010negative bacteria to deliver toxins into adjacent target cells.\n                    <jats:italic>Vibrio cholerae<\/jats:italic>\n                    , the bacterium responsible for the fatal water\u2010borne cholera disease, uses the T6SS to evade phagocytic eukaryotes, cause intestinal inflammation, and compete against other bacteria with toxins that disrupt lipid membranes, cell walls and actin cytoskeletons. The control of T6SS genes varies among\n                    <jats:italic>V. cholerae<\/jats:italic>\n                    strains and typically includes inputs from external signals and cues, such as quorum sensing and chitin availability. In the following review, we highlight the repertoire of toxic T6SS effectors and the diverse genetic regulation networks among different isolates of\n                    <jats:italic>V. cholerae<\/jats:italic>\n                    . Finally, we discuss the roles played by the T6SS of\n                    <jats:italic>V. cholerae<\/jats:italic>\n                    in both natural environments and hosts.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.14976","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T20:47:50Z","timestamp":1583354870000},"page":"4112-4122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["The\n                    <scp>\n                      <i>Vibrio cholerae<\/i>\n                    <\/scp>\n                    type VI secretion system: toxins, regulators and consequences"],"prefix":"10.1111","volume":"22","author":[{"given":"Cristian V.","family":"Crisan","sequence":"first","affiliation":[{"name":"Center for Microbial Dynamics and Infection Georgia Institute of Technology  Atlanta GA USA"},{"name":"Institute for Bioengineering and Biosciences, Georgia Institute of 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