{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:53:06Z","timestamp":1793141586985,"version":"4.5.0"},"reference-count":69,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["QREN_NORTE\u201001\u20100145\u2010FEDER\u2010000011"],"award-info":[{"award-number":["QREN_NORTE\u201001\u20100145\u2010FEDER\u2010000011"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["QREN_NORTE\u201001\u20100145\u2010FEDER\u2010000024"],"award-info":[{"award-number":["QREN_NORTE\u201001\u20100145\u2010FEDER\u2010000024"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/137100\/2018"],"award-info":[{"award-number":["SFRH\/BD\/137100\/2018"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04378\/2020"],"award-info":[{"award-number":["UIDB\/04378\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Microbiology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Emergence and expansion of frequent multidrug\u2010resistant (MDR) major\n                    <jats:italic>Salmonella<\/jats:italic>\n                    clones\/serotypes has been a significant threat in the last years. Metal compounds, such as copper, commonly used in animal\u2010production settings, have been pointed out as possible contributors for the selection of such strains\/clones. However, the scarcity of studies limits our understanding of the impact of other metal environmental contaminants as arsenic (used in insecticides\/herbicides\/coccidiostats). We analysed arsenic tolerance (AsT) dispersion by phenotypic and genotypic (PCR\/sequencing\/I\u2010\n                    <jats:italic>Ceu<\/jats:italic>\n                    I\/S1\/\n                    <jats:italic>Xba<\/jats:italic>\n                    I\u2010PFGE\/hybridization) assays among\n                    <jats:italic>Salmonella<\/jats:italic>\n                    with diverse epidemiological and genetic backgrounds. Then, to better understand\n                    <jats:italic>ars<\/jats:italic>\n                    operon genetic contexts, the whole genome of five representative strains was sequenced. We found a high dispersion of\n                    <jats:italic>ars<\/jats:italic>\n                    operons conferring AsT, especially among copper\u2010tolerant and relevant serotypes\/clones related to pig\u2010production setting. The\n                    <jats:italic>acr3<\/jats:italic>\n                    \u2010type was found dispersed in the chromosome of diverse serotypes, including the emergent\n                    <jats:italic>S<\/jats:italic>\n                    . Rissen. Conversely,\n                    <jats:italic>arsB<\/jats:italic>\n                    II was almost confined to the MDR ST34 European clone of\n                    <jats:italic>S<\/jats:italic>\n                    . Typhimurium\/\n                    <jats:italic>S<\/jats:italic>\n                    . 4,[5],12:i:\u2010, always along with copper\/silver tolerance\n                    <jats:italic>sil<\/jats:italic>\n                    +\n                    <jats:italic>pco<\/jats:italic>\n                    clusters in an integrative conjugative element. These data suggest that AsT is an essential adaptive feature for the ecological success of these epidemic clones\/serotypes and alerts for global strategies to reduce arsenic\u2010based compounds' impact thus preventing environmental\/food contamination with frequent MDR foodborne pathogens.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.15016","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T06:13:46Z","timestamp":1586758426000},"page":"2829-2842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Tolerance to arsenic contaminant among multidrug\u2010resistant and copper\u2010tolerant\n                    <scp>\n                      <i>Salmonella<\/i>\n                    <\/scp>\n                    successful clones is associated with diverse\n                    <scp>\n                      <i>ars<\/i>\n                    <\/scp>\n                    operons and genetic contexts"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1296-5964","authenticated-orcid":false,"given":"Joana","family":"Mour\u00e3o","sequence":"first","affiliation":[{"name":"UCIBIO\/REQUIMTE Department of Biological Sciences, Laboratory of Microbiology, Faculty of Pharmacy, University of Porto  Porto Portugal"},{"name":"Center for Innovative Biomedicine and Biotechnology University of Coimbra  Coimbra Portugal"},{"name":"Center for Neuroscience and Cell Biology University of Coimbra  Coimbra Portugal"},{"name":"Institute for Interdisciplinary Research, University of Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreia","family":"Rebelo","sequence":"additional","affiliation":[{"name":"UCIBIO\/REQUIMTE Department of Biological Sciences, Laboratory of Microbiology, Faculty of Pharmacy, University of Porto  Porto Portugal"},{"name":"Scientific Area of Environmental Health School of Health, Polytechnic Institute of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"UCIBIO\/REQUIMTE Department of Biological Sciences, Laboratory of Microbiology, Faculty of Pharmacy, University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00edsa","family":"Peixe","sequence":"additional","affiliation":[{"name":"UCIBIO\/REQUIMTE Department of Biological Sciences, Laboratory of Microbiology, Faculty of Pharmacy, University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Novais","sequence":"additional","affiliation":[{"name":"UCIBIO\/REQUIMTE Department of Biological Sciences, Laboratory of Microbiology, Faculty of Pharmacy, University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3553-2678","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Antunes","sequence":"additional","affiliation":[{"name":"UCIBIO\/REQUIMTE Department of Biological Sciences, Laboratory of Microbiology, Faculty of Pharmacy, University of Porto  Porto Portugal"},{"name":"Faculty of Nutrition and Food Sciences University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110726"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep35527"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuv050"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.12.004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00429-19"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2018.11.007"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-9-75"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/cmb.2012.0021"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2010.0702"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/jbiol91"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr846"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02033-08"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01118"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3176"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-012-4678-8"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2016.21.26.30270"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv409"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens8010019"},{"key":"e_1_2_7_21_1","unstructured":"CLSI \u2010 Clinical & Laboratory Standards Institute(2018) Performance Standards for Antimicrobial Susceptibility Testing 28th informational supplement. CLSI Document M100\u2010S28. Wayne PA."},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-017-9028-z"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx607"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fux008"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-019-0661-5"},{"key":"e_1_2_7_26_1","first-page":"3597","article-title":"Dietary exposure to inorganic arsenic in the European population","volume":"12","author":"EFSA \u2010 European Food Safety Authority","year":"2014","journal-title":"EFSA J"},{"key":"e_1_2_7_27_1","first-page":"4666","article-title":"EMA and EFSA joint scientific opinion on measures to reduce the need to use antimicrobial agents in animal husbandry in the European Union, and the resulting impacts on food safety (RONAFA)","volume":"15","author":"EFSA \u2010 European Food Safety Authority","year":"2017","journal-title":"EFSA J"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2009.1351"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2019.5598"},{"key":"e_1_2_7_30_1","first-page":"5500","article-title":"The European Union summary report on trends and sources of zoonoses, zoonotic agents and food\u2010borne outbreaks in 2017","volume":"16","author":"EFSA \u2010 European Food Safety Authority","year":"2018","journal-title":"EFSA J"},{"key":"e_1_2_7_31_1","unstructured":"EMA \u2010 European Medicines Agency(2016) Update advice on the use of colistin products in animals within the European Union: development of resistance and possible impact on human and animal health. EMA\/CVMP\/CHMP\/231573\/2016.https:\/\/www.ema.europa.eu\/en\/documents\/scientific-guideline\/updated-advice-use-colistin-products-animals-within-european-union-development-resistance-possible_en-0.pdf."},{"key":"e_1_2_7_32_1","unstructured":"EUCAST \u2010 European Committee on Antimicrobial Susceptibility Testing(2019) The European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters Version 9.0."},{"key":"e_1_2_7_33_1","first-page":"1","article-title":"Distribution of arsenic resistance genes in prokaryotes","volume":"9","author":"Fekih I.B.","year":"2018","journal-title":"Front Microbiol"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/1758-2229.12167"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2017.2418"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.02.058"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq101"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-017-0003-4"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2019.01.076"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0209072"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1637\/9285-022210-Reg.1"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky352"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01371-09"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00715"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-014-2180-1"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw120"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2015.01.013"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0030053"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1206245"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2011.12.022"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph10083453"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2204.150531"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2017.04.010"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2014.02.019"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soilbio.2006.12.015"},{"key":"e_1_2_7_56_1","volume-title":"Nanosilver: Safety, Health and Environmental Effects and Role in Antimicrobial Resistance","author":"SCENIHR \u2010 Scientific Committee on Emerging and Newly Identified Health Risks","year":"2014"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr039"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2015.12.017"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-016-0001-8"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2014.06.067"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00294-018-0894-9"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.20.6991-6997.2005"},{"key":"e_1_2_7_63_1","first-page":"5","article-title":"New mechanisms of bacterial arsenic resistance","volume":"39","author":"Yang H.C.","year":"2016","journal-title":"Biom J"},{"key":"e_1_2_7_64_1","first-page":"1","article-title":"Zinc and copper in animal feed development of resistance and co\u2010resistance to antimicrobial agents in bacteria of animal origin","volume":"1","author":"Yazdankhah S.","year":"2014","journal-title":"Microb Ecol Heal Dis"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147101"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fm.2016.12.009"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks261"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph9082658"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plasmid.2018.09.007"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10482-009-9313-z"}],"container-title":["Environmental Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1462-2920.15016","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1462-2920.15016","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1462-2920.15016","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/sfamjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1462-2920.15016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:17:53Z","timestamp":1761862673000},"score":1,"resource":{"primary":{"URL":"https:\/\/sfamjournals.onlinelibrary.wiley.com\/doi\/10.1111\/1462-2920.15016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,30]]},"references-count":69,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1111\/1462-2920.15016"],"URL":"https:\/\/doi.org\/10.1111\/1462-2920.15016","archive":["Portico"],"relation":{},"ISSN":["1462-2912","1462-2920"],"issn-type":[{"value":"1462-2912","type":"print"},{"value":"1462-2920","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,30]]},"assertion":[{"value":"2019-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}