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This practice has led to the emergence of multiresistant bacteria such as\n                    <jats:italic>Salmonella<\/jats:italic>\n                    , of which some serovars are disseminated in the environment. The objective of this study is to evaluate microcin J25 as an inhibitor of\n                    <jats:italic>Salmonella enterica<\/jats:italic>\n                    serovars of various origins including human, livestock and food. Among the 116 isolates tested, 37 (31.8%) were found resistant to at least one antibiotic, and 28 were multiresistant with 19 expressing the penta\u2010resistant phenotype ACSSuT. Microcin J25 inhibited all isolates, with minimal inhibitory concentration values ranging from 0.06\u2009\u03bcg\/ml (28.4\u2009nM) to 400\u2009\u03bcg\/ml (189\u2009\u03bcM). Interestingly, no cross\u2010resistance was found between microcin J25 and antibiotics. Multiple sequence alignments of genes encoding for the different proteins involved in the recognition and transport of microcin J25 showed that only ferric\u2010hydroxamate uptake is an essential determinant for susceptibility of\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>enterica<\/jats:italic>\n                    to microcin J25. Examination of\n                    <jats:italic>Salmonella<\/jats:italic>\n                    strains exposed to microcin J25 by transmission electronic microscopy showed for the first\u2010time involvement of a pore formation mechanism. Microcin J25 was a strong inhibitor of several multiresistant isolates of\n                    <jats:italic>Salmonella<\/jats:italic>\n                    and may have a great potential as an alternative to antibiotics.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.15045","type":"journal-article","created":{"date-parts":[[2020,5,3]],"date-time":"2020-05-03T23:35:08Z","timestamp":1588548908000},"page":"2907-2920","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Phenomic and genomic approaches to studying the inhibition of multiresistant\n                    <scp>\n                      <i>Salmonella enterica<\/i>\n                    <\/scp>\n                    by microcin\n                    <scp>J25<\/scp>"],"prefix":"10.1111","volume":"22","author":[{"given":"Laila","family":"Ben Said","sequence":"first","affiliation":[{"name":"Institute of Nutrition and Functional Foods Universit\u00e9 Laval  Qu\u00e9bec Quebec G1V 0A6 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Guillaume","family":"Emond\u2010Rheault","sequence":"additional","affiliation":[{"name":"Institute of Integrative Biology and Systems Universit\u00e9 Laval  QC Qu\u00e9bec G1V 0A6 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Soltani","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Functional Foods Universit\u00e9 Laval  Qu\u00e9bec Quebec G1V 0A6 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofiane","family":"Telhig","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Functional Foods Universit\u00e9 Laval  Qu\u00e9bec Quebec G1V 0A6 Canada"},{"name":"Mus\u00e9um National d'Histoire Naturelle Centre National de la Recherche Scientifique, Laboratory of Communication Molecules and Adaptation of Micro\u2010organisms, UMR 7245 CNRS\u2010MNHN  Paris CP 54, 57 rue Cuvier 75005 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Zirah","sequence":"additional","affiliation":[{"name":"Mus\u00e9um National d'Histoire Naturelle Centre National de la Recherche Scientifique, Laboratory of Communication Molecules and Adaptation of Micro\u2010organisms, UMR 7245 CNRS\u2010MNHN  Paris CP 54, 57 rue Cuvier 75005 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Rebuffat","sequence":"additional","affiliation":[{"name":"Mus\u00e9um National d'Histoire Naturelle Centre National de la Recherche Scientifique, Laboratory of Communication Molecules and Adaptation of Micro\u2010organisms, UMR 7245 CNRS\u2010MNHN  Paris CP 54, 57 rue Cuvier 75005 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moussa Sory","family":"Diarra","sequence":"additional","affiliation":[{"name":"Guelph Research and Development Center Agriculture and Agri\u2010Food Canada  93 Stone Road West, Guelph Ontario N1G 5C9 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Goodridge","sequence":"additional","affiliation":[{"name":"Department of Food Science and Agriculture McGill University  Ste Anne de Bellevue, Qu\u00e9bec Quebec H9X3V9 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger C.","family":"Levesque","sequence":"additional","affiliation":[{"name":"Institute of Integrative Biology and Systems Universit\u00e9 Laval  QC Qu\u00e9bec G1V 0A6 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8467-9414","authenticated-orcid":false,"given":"Ismail","family":"Fliss","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Functional Foods Universit\u00e9 Laval  Qu\u00e9bec Quebec G1V 0A6 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2NP20085F"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S173867"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2015.11.005"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00206-07"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201797278"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1817352116"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.6.2137-2140.2001"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.45.839"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1320506111"},{"key":"e_1_2_5_11_1","unstructured":"CIPARS Canadian integrated program for antimicrobial resistance surveillance(2016). 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