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Immune cells of the innate immune system serve as the first line of defence against inhaled spores. Alveolar macrophages were challenged with the mucoralean fungus\n                    <jats:italic>Lichtheimia corymbifera<\/jats:italic>\n                    and subjected to biotinylation and streptavidin enrichment procedures followed by LC\u2013MS\/MS analyses. A total of 28 host proteins enriched for binding to macrophage\u2013\n                    <jats:italic>L<\/jats:italic>\n                    .\n                    <jats:italic>corymbifera<\/jats:italic>\n                    interaction. Among those, the HSP70\u2010family protein Hspa8 was found to be predominantly responsive to living and heat\u2010killed spores of a virulent and an attenuated strain of\n                    <jats:italic>L<\/jats:italic>\n                    .\n                    <jats:italic>corymbifera<\/jats:italic>\n                    . Confocal scanning laser microscopy of infected macrophages revealed colocalization of Hspa8 with phagocytosed spores of\n                    <jats:italic>L<\/jats:italic>\n                    .\n                    <jats:italic>corymbifera<\/jats:italic>\n                    . The amount of detectable Hspa8 was dependent on the multiplicity of infection. Incubation of alveolar macrophages with an anti\u2010Hspa8 antibody prior to infection reduced their capability to phagocytose spores of\n                    <jats:italic>L<\/jats:italic>\n                    .\n                    <jats:italic>corymbifera<\/jats:italic>\n                    . In contrast, anti\u2010Hspa8 antibodies did not abrogate the phagocytosis of\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    conidia by macrophages. These results suggest an important contribution of the heat\u2010shock family protein Hspa8 in the recognition of spores of the mucoralean fungus\n                    <jats:italic>L<\/jats:italic>\n                    .\n                    <jats:italic>corymbifera<\/jats:italic>\n                    by host alveolar macrophages and define a potential immunomodulatory therapeutic target.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.15140","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T21:14:35Z","timestamp":1593033275000},"page":"3722-3740","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Functional surface proteomic profiling reveals the host heat\u2010shock protein\n                    <scp>A8<\/scp>\n                    as a mediator of\n                    <i>Lichtheimia corymbifera<\/i>\n                    recognition by murine alveolar macrophages"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2439-1953","authenticated-orcid":false,"given":"Mohamed I. 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