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Expectations for a vaccine are high while the case numbers continue to rise. As of mid\u2010August 2020, more than 20 million people have been infected and more than 760\u2009000 lives have been lost worldwide. The threat of this virus to health, the economy and to society is so great that the wish for a fast track vaccine is understandable, but how realistic is it? This survey article tries to give an overview of vaccine candidates in development, including preclinical and clinical testing, and it mentions some of the societal problems of vaccine acceptance.<\/jats:p>","DOI":"10.1111\/1462-2920.15225","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T03:52:51Z","timestamp":1599623571000},"page":"4071-4084","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Efforts towards a\n                    <scp>COVID<\/scp>\n                    \u201019 vaccine"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4783-8583","authenticated-orcid":false,"given":"Harald","family":"Br\u00fcssow","sequence":"first","affiliation":[{"name":"Department of Biosystems, Laboratory of Gene Technology KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,28]]},"reference":[{"key":"e_1_2_27_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.03.007"},{"key":"e_1_2_27_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-020-01452-z"},{"key":"e_1_2_27_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc1463"},{"key":"e_1_2_27_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe2024894"},{"key":"e_1_2_27_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-020-02386-2"},{"key":"e_1_2_27_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.07.018"},{"key":"e_1_2_27_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.368.6486.14"},{"key":"e_1_2_27_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc0006"},{"key":"e_1_2_27_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.368.6490.456"},{"key":"e_1_2_27_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.06.11.145920"},{"key":"e_1_2_27_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31025-4"},{"key":"e_1_2_27_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.08.002"},{"key":"e_1_2_27_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1223"},{"key":"e_1_2_27_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp2020076"},{"key":"e_1_2_27_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abc9396"},{"key":"e_1_2_27_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31604-4"},{"key":"e_1_2_27_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr2009737"},{"key":"e_1_2_27_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc1932"},{"key":"e_1_2_27_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31527-0"},{"key":"e_1_2_27_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.8189"},{"key":"e_1_2_27_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.08.026"},{"key":"e_1_2_27_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe2025111"},{"key":"e_1_2_27_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2022483"},{"key":"e_1_2_27_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2281-1"},{"key":"e_1_2_27_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-020-01063"},{"key":"e_1_2_27_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.07.019"},{"key":"e_1_2_27_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30796-0"},{"key":"e_1_2_27_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.12461"},{"key":"e_1_2_27_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp2020926"},{"key":"e_1_2_27_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2607-z"},{"key":"e_1_2_27_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30317-0"},{"key":"e_1_2_27_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2020.100073"},{"key":"e_1_2_27_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.12190"},{"key":"e_1_2_27_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0337-y"},{"key":"e_1_2_27_36_1","unstructured":"The Economist(2020) First world problem. 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