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Though the average human inhales hundreds of conidia daily,\n                    <jats:italic>A. fumigatus<\/jats:italic>\n                    invasive infections primarily affect the immunocompromised. At\u2010risk individuals can develop often fatal invasive disease for which therapeutic options are limited. Regrettably, the global insurgence of isolates resistant to the triazoles, the frontline antifungal class used in medicine and agriculture to control\n                    <jats:italic>A. fumigatus<\/jats:italic>\n                    , is complicating the treatment of patients. Triazole antifungal resistance in\n                    <jats:italic>A. fumigatus<\/jats:italic>\n                    has become recognized as a global, yet poorly comprehended, problem. Due to a multitude of factors, the magnitude of resistant infections and their contribution to treatment outcomes are likely underestimated. Current studies suggest that human drug\u2010resistant infections can be either environmentally acquired or\n                    <jats:italic>de novo<\/jats:italic>\n                    host selected during patient therapy. While much concerning development of resistance is yet unknown, recent investigations have revealed assorted underlying mechanisms enabling triazole resistance within individual clinical and environmental isolates. This review will provide an overview of triazole resistance as it is currently understood, as well as highlight some of the prominent biological mechanisms associated with clinical and environmental resistance to triazoles in\n                    <jats:italic>A. fumigatus<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.15274","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T23:51:22Z","timestamp":1602546682000},"page":"4934-4952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Mechanisms of triazole resistance in\n                    <i>Aspergillus fumigatus<\/i>"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4969-4192","authenticated-orcid":false,"given":"Ashley V.","family":"Nywening","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy and Translational Sciences The University of Tennessee Health Science Center, 881 Madison Avenue  Memphis TN USA"},{"name":"College of Graduate Health Sciences, Integrated Biomedical Sciences Program The University of Tennessee Health Science Center  Memphis TN 38163 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Rybak","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Translational Sciences The University of Tennessee Health Science Center, 881 Madison Avenue  Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip David","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Translational Sciences The University of Tennessee Health Science Center, 881 Madison Avenue  Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarrod R.","family":"Fortwendel","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Translational Sciences The University of Tennessee Health Science Center, 881 Madison Avenue  Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,21]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"e00536","article-title":"'Genomic context of azole resistance mutations in Aspergillus fumigatus determined using whole\u2010genome sequencing","volume":"6","author":"Abdolrasouli A.","year":"2015","journal-title":"mBio"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00446-17"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652015000700011"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00275514.2018.1557796"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/15572536.2006.11832836"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02513-10"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010080"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp751"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00854-09"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00167-13"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof4010039"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01492-08"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693780902717018"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof6020075"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof3040057"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1920497117"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00595-17"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/2110-5820-2-6"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158724"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004404"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq279"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007858"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes10110855"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050034"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00335-12"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05088-11"},{"key":"e_1_2_5_28_1","unstructured":"CDC. 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