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Low ambient dissolved iron concentrations in many aquatic environments mean that these organisms must maintain sufficient and selective transport of iron into the cell. However, the nature of iron transport pathways through the cyanobacterial outer membrane remains obscure. Here we present multiple lines of experimental evidence that collectively support the existence of a novel class of substrate\u2010selective iron porin, Slr1908, in the outer membrane of the cyanobacterium\n                    <jats:italic>Synechocystis<\/jats:italic>\n                    sp. PCC 6803. Elemental composition analysis and short\u2010term iron uptake assays with mutants in Slr1908 reveal that this protein is primarily involved in inorganic iron uptake and contributes less to the accumulation of other metals. Homologues of Slr1908 are widely distributed in both freshwater and marine cyanobacteria, most notably in unicellular marine diazotrophs. Complementary experiments with a homologue of Slr1908 in\n                    <jats:italic>Synechococcus<\/jats:italic>\n                    sp. PCC 7002 restored the phenotype of\n                    <jats:italic>Synechocystis<\/jats:italic>\n                    knockdown mutants, showing that this siderophore producing species also possesses a porin with a similar function in Fe transport. The involvement of a substrate\u2010selective porins in iron uptake may allow cyanobacteria to tightly control iron flux into the cell, particularly in environments where iron concentrations fluctuate.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.15324","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T06:22:31Z","timestamp":1605507751000},"page":"376-390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["A unique porin meditates iron\u2010selective transport through cyanobacterial outer membranes"],"prefix":"10.1111","volume":"23","author":[{"given":"Guo\u2010Wei","family":"Qiu","sequence":"first","affiliation":[{"name":"School of Life Sciences, Hubei Key Laboratory of Genetic Regulation and Integrative Biology Central China Normal University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3515-4398","authenticated-orcid":false,"given":"Hai\u2010Bo","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Hubei Key Laboratory of Genetic Regulation and Integrative Biology Central China Normal University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagar","family":"Lis","sequence":"additional","affiliation":[{"name":"Department of Plant and Environmental Sciences The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng\u2010Ke","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Hubei Key Laboratory of Genetic Regulation and Integrative Biology Central China Normal University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Hubei Key Laboratory of Genetic Regulation and Integrative Biology Central China Normal University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6922-7129","authenticated-orcid":false,"given":"Jin\u2010Long","family":"Shang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Hubei Key Laboratory of Genetic Regulation and Integrative Biology Central China Normal University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan\u2010Yu","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Hubei Key Laboratory of Genetic Regulation and Integrative Biology Central China Normal University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Keren","sequence":"additional","affiliation":[{"name":"Department of Plant and Environmental Sciences The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. 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