{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T22:00:41Z","timestamp":1788300041195,"version":"build-2803163510"},"reference-count":66,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T00:00:00Z","timestamp":1614470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["SFI\/12\/RC\/2273\u2010P1"],"award-info":[{"award-number":["SFI\/12\/RC\/2273\u2010P1"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["SFI\/12\/RC\/2273\u2010P2"],"award-info":[{"award-number":["SFI\/12\/RC\/2273\u2010P2"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Microbiology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The human vaginal environment harbours a community of bacteria that plays an important role in maintaining vaginal health and in protecting this environment from various urogenital infections. This bacterial population, also known as vaginal microbiota, has been demonstrated to be dominated by members of the\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    genus. Several studies employing 16S rRNA gene\u2010based amplicon sequencing have classified the vaginal microbiota into five distinct community state types (CSTs) or vaginotypes. To deepen our understanding of the vaginal microbiota we performed an in\u2010depth meta\u2010analysis of 1312 publicly available datasets concerning healthy vaginal microbiome information obtained by metagenomics sequencing. The analysis confirmed the predominance of taxa belonging to the\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    genus, followed by members of the genera\n                    <jats:italic>Gardnerella<\/jats:italic>\n                    ,\n                    <jats:italic>Vibrio<\/jats:italic>\n                    and\n                    <jats:italic>Atopobium<\/jats:italic>\n                    . Moreover, the statistical robustness offered by this meta\u2010analysis allowed us to disentangle the species\u2010level composition of dominant and accessory taxa constituting each vaginotype and to revisit and refine the previously proposed CST classification. In addition, a functional characterization of the metagenomic datasets revealed particular genetic features associated with each assigned vaginotype.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.15441","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T01:48:10Z","timestamp":1613958490000},"page":"1780-1792","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Vaginotypes of the human vaginal microbiome"],"prefix":"10.1111","volume":"23","author":[{"given":"Leonardo","family":"Mancabelli","sequence":"first","affiliation":[{"name":"Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability University of Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Tarracchini","sequence":"additional","affiliation":[{"name":"Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability University of Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Milani","sequence":"additional","affiliation":[{"name":"Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability University of Parma  Parma Italy"},{"name":"Interdepartmental Research Centre \"Microbiome Research Hub\" University of Parma  Parma 43124 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele Andrea","family":"Lugli","sequence":"additional","affiliation":[{"name":"Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability University of Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Fontana","sequence":"additional","affiliation":[{"name":"Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability University of Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5363-0231","authenticated-orcid":false,"given":"Francesca","family":"Turroni","sequence":"additional","affiliation":[{"name":"Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability University of Parma  Parma Italy"},{"name":"Interdepartmental Research Centre \"Microbiome Research Hub\" University of Parma  Parma 43124 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douwe","family":"van Sinderen","sequence":"additional","affiliation":[{"name":"APC Microbiome Institute and School of Microbiology, Bioscience Institute National University of Ireland  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4875-4560","authenticated-orcid":false,"given":"Marco","family":"Ventura","sequence":"additional","affiliation":[{"name":"Laboratory of Probiogenomics, 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