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In this study, we characterized a putative orthologue of yeast SPE1 in\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>higginsianum<\/jats:italic>\n                    , named ChODC. Deletion mutants of\n                    <jats:italic>ChODC<\/jats:italic>\n                    were defective in hyphal and conidial development. Importantly, deletion of\n                    <jats:italic>ChODC<\/jats:italic>\n                    significantly affected appressorium\u2010mediated penetration in\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>higginsianum<\/jats:italic>\n                    . However, polyamines partially restore appressorium function and virulence indicating that loss of\n                    <jats:italic>ChODC<\/jats:italic>\n                    caused significantly decreased virulence by the crosstalk between polyamines and other metabolic pathways. Subsequently, transcriptomic and metabolomic analyses demonstrated that\n                    <jats:italic>ChODC<\/jats:italic>\n                    played an important role in metabolism of various carbon and nitrogen compounds including amino acids, carbohydrates and lipids. Along with these clues, we found deletion of\n                    <jats:italic>ChODC<\/jats:italic>\n                    affected glycogen and lipid metabolism, which were important for conidial storage utilization and functional appressorium formation. Loss of\n                    <jats:italic>ChODC<\/jats:italic>\n                    affected the mTOR signalling pathway via modulation of autophagy. Interestingly, cAMP treatment restored functional appressoria to the \u0394\n                    <jats:italic>ChODC<\/jats:italic>\n                    mutant, and rapamycin treatment also stimulated formation of functional appressoria in the \u0394\n                    <jats:italic>ChODC<\/jats:italic>\n                    mutant. Overall,\n                    <jats:italic>ChODC<\/jats:italic>\n                    was associated with the polyamine biosynthesis pathway, as a mediator of cAMP and mTOR signalling pathways to regulate appressorium function. Our study provides evidence of a link between ChODC and the cAMP signalling pathway and defines a novel mechanism by which ChODC regulates infection\u2010associated autophagy and plant infection by fungi.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.15755","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T01:02:55Z","timestamp":1630544575000},"page":"1093-1116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Ornithine decarboxylase of the fungal pathogen\n                    <i>Colletotrichum higginsianum<\/i>\n                    plays an important role in regulating global metabolic pathways and virulence"],"prefix":"10.1111","volume":"24","author":[{"given":"Yaqin","family":"Yan","sequence":"first","affiliation":[{"name":"Institute of Vegetable, Zhejiang Academy of Agricultural Science  Hangzhou 310021 China"},{"name":"State Key Laboratory of Agricultural Microbiology\/Hubei Key Laboratory of Plant Pathology Huazhong Agricultural University  Wuhan 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintian","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology\/Hubei Key Laboratory of Plant Pathology Huazhong Agricultural University  Wuhan 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinfeng","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology\/Hubei Key Laboratory of Plant Pathology Huazhong Agricultural University  Wuhan 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology\/Hubei Key Laboratory of Plant Pathology Huazhong Agricultural University  Wuhan 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbin","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology\/Hubei Key Laboratory of Plant Pathology Huazhong Agricultural University  Wuhan 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Hsiang","sequence":"additional","affiliation":[{"name":"School of Environmental Sciences University of Guelph  Guelph ON N1G 2W1 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chonglai","family":"Bao","sequence":"additional","affiliation":[{"name":"Institute of Vegetable, Zhejiang Academy of Agricultural Science  Hangzhou 310021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2414-1671","authenticated-orcid":false,"given":"Lu","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology\/Hubei Key Laboratory of Plant Pathology Huazhong Agricultural University  Wuhan 430070 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-009-0396-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.108.060996"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(76)91182-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.19.14242"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2009.03984.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(84)91570-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/mp\/sst080"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1094\/PHYTO.1998.88.1.58"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fm.2015.01.020"},{"key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-3-662-44053-7_3","volume-title":"The Genomics of Colletotrichum. 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