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For an accelerated use of antivirals in the clinic, most SARS\u2010CoV\u20102 antivirals represented repurposed drugs. The present article summarizes the outcomes of clinical trials with antiviral drugs in COVID\u201019 patients. Many antiviral drugs failed to demonstrate beneficial effects or showed mixed results. One reason for the low success rate of clinical trials was shortcomings of antiviral tests in cell culture systems and another reason was the abundance of ill\u2010coordinated and underpowered clinical trials. However, large pragmatic clinical trials particularly of the British RECOVERY trial series demonstrated that even under emergency situation drug trials can be conducted in a timely way such that the therapy of COVID\u201019 patients can be based on evidence basis instead on expert opinion or even worse on political pressure.<\/jats:p>","DOI":"10.1111\/1462-2920.15769","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T04:04:02Z","timestamp":1631592242000},"page":"6364-6376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Clinical trials with antiviral drugs against\n                    <scp>COVID<\/scp>\n                    \u201019: some progress and many shattered hopes"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4783-8583","authenticated-orcid":false,"given":"Harald","family":"Br\u00fcssow","sequence":"first","affiliation":[{"name":"Department of Biosystems, Laboratory of Gene Technology KU Leuven  Leuven 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