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The initial steps of rhizobium\u2010legumes symbioses involve the reciprocal recognition by chemical signals, being luteolin one of the molecules involved. However, there is a lack of information on the effect of luteolin in beta\u2010rhizobia. In this work, we used long\u2010read sequencing to complete the genome of UYPR2.512 providing evidence for the existence of four closed circular replicons. We used an RNA\u2010Seq approach to analyse the response of UYPR2.512 to luteolin. One hundred and forty\u2010five genes were differentially expressed, with similar numbers of downregulated and upregulated genes. Most repressed genes were mapped to the main chromosome, while the upregulated genes were overrepresented among pCne512e, containing the symbiotic genes. Induced genes included the\n                    <jats:italic>nod<\/jats:italic>\n                    operon and genes implicated in exopolysaccharides and flagellar biosynthesis. We identified many genes involved in iron, copper and other heavy metals metabolism. Among repressed genes, we identified genes involved in basal carbon and nitrogen metabolism. Our results suggest that in response to luteolin,\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>necator<\/jats:italic>\n                    strain UYPR2.512 reshapes its metabolism in order to be prepared for the forthcoming symbiotic interaction.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.15845","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T22:20:57Z","timestamp":1637619657000},"page":"240-264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Genomics and transcriptomics insights into luteolin effects on the beta\u2010rhizobial strain\n                    <i>Cupriavidus necator<\/i>\n                    UYPR2.512"],"prefix":"10.1111","volume":"24","author":[{"given":"M. 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