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Prolonged exposure to solar UV radiation can cause deleterious effects by inducing two major types of DNA damage, namely, cyclobutane pyrimidine dimers (CPDs) and pyrimidine 6\u20104 pyrimidone photoproducts. These lesions may be repaired by the photoreactivation (Phr) and nucleotide excision repair (NER) pathways; however, the principal UV\u2010induced DNA repair pathway is not known in the fungal genus\n                    <jats:italic>Pseudogymnoascus<\/jats:italic>\n                    . In this study, we demonstrated that an unweighted UV\u2010B dosage of 1.6\u00a0kJ\u2009m\n                    <jats:sup>\u22122<\/jats:sup>\n                    d\n                    <jats:sup>\u22121<\/jats:sup>\n                    significantly reduced fungal growth rates (by between 22% and 35%) and inhibited conidia production in a 10 d exposure. The comparison of two DNA repair conditions, light or dark, which respectively induced photoreactivation (Phr) and NER, showed that the UV\u2010B\u2010induced CPDs were repaired significantly more rapidly in light than in dark conditions. The expression levels of two DNA repair genes,\n                    <jats:italic>RAD2<\/jats:italic>\n                    and\n                    <jats:italic>PHR1<\/jats:italic>\n                    (encoding a protein in NER and Phr respectively), demonstrated that NER rather than Phr was primarily activated for repairing UV\u2010B\u2010induced DNA damage in these\n                    <jats:italic>Pseudogymnoascus<\/jats:italic>\n                    strains. In contrast, Phr was inhibited after exposure to UV\u2010B radiation, suggesting that\n                    <jats:italic>PHR1<\/jats:italic>\n                    may have other functional roles. We present the first study to examine the capability of the Arctic and Antarctic\n                    <jats:italic>Pseudogymnoascus<\/jats:italic>\n                    sp. to perform photoreactivation and\/or NER via RT\u2010qPCR approaches, and also clarify the effects of light on UV\u2010B\u2010induced DNA damage repair\n                    <jats:italic>in vivo<\/jats:italic>\n                    by quantifying cyclobutene pyrimidine dimers and pyrimidine 6\u20104 pyrimidone photoproducts. Physiological response data, including relative growth rate, pigmentation and conidia production in these\n                    <jats:italic>Pseudogymnoascus<\/jats:italic>\n                    isolates exposed to UV\u2010B radiation are also presented.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.16073","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T05:33:57Z","timestamp":1653629637000},"page":"3164-3180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<scp>UV\u2010B<\/scp>\n                    \u2010induced\n                    <scp>DNA<\/scp>\n                    damage and repair pathways in polar\n                    <i>Pseudogymnoascus<\/i>\n                    sp. from the Arctic and Antarctic regions and their effects on growth, pigmentation and conidiogenesis"],"prefix":"10.1111","volume":"24","author":[{"given":"Hao Jie","family":"Wong","sequence":"first","affiliation":[{"name":"Laboratory of Gene Regulation Research, Division of Biological Science Nara Institute of Science and Technology, Ikoma  Nara 630\u20100192 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuradilla","family":"Mohamad\u2010Fauzi","sequence":"additional","affiliation":[{"name":"Institute of Ocean and Earth Sciences, Institute for Advanced Studies Universiti Malaya, Lembah Pantai  50603 Kuala Lumpur Malaysia"},{"name":"Faculty of Science, Institute of Biological Sciences Universiti Malaya, Lembah Pantai  50603 Kuala Lumpur Malaysia"},{"name":"National Antarctic Research Centre, Institute for Advanced Studies Universiti Malaya, 50603 Lembah Pantai  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Rizman\u2010Idid","sequence":"additional","affiliation":[{"name":"Institute of Ocean and Earth Sciences, Institute for Advanced Studies Universiti Malaya, Lembah Pantai  50603 Kuala Lumpur Malaysia"},{"name":"National Antarctic Research Centre, Institute for Advanced Studies Universiti Malaya, 50603 Lembah Pantai  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Convey","sequence":"additional","affiliation":[{"name":"National Antarctic Research Centre, Institute for Advanced Studies Universiti Malaya, 50603 Lembah Pantai  Kuala Lumpur Malaysia"},{"name":"British Antarctic Survey, NERC, High Cross, Madingley Road  Cambridge CB3 OET UK"},{"name":"Department of Zoology University of Johannesburg, PO Box 524  Auckland Park 2006 South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Smykla","sequence":"additional","affiliation":[{"name":"Institute of Nature Conservation Polish Academy of Sciences, Mickiewicza 33  31\u2010120 Krak\u00f3w 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