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Such infections are generally complex, and recognized as polymicrobial in nature. Both\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    and\n                    <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                    can cause chronic lung infections and were both detected in cystic fibrosis (CF) lung at different stages. In this study, single and dual species cultures of\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    and\n                    <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                    were studied under well\u2010controlled planktonic growth conditions. Under pH\u2010controlled conditions, both species apparently benefited from the presence of the other. In co\u2010culture with\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>aeruginosa<\/jats:italic>\n                    ,\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>pneumoniae<\/jats:italic>\n                    grew efficiently under aerobic conditions, whereas in pure\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>pneumoniae<\/jats:italic>\n                    culture, growth inhibition occurred in bioreactors with dissolved oxygen concentrations above the microaerobic range. Lactic acid and acetoin that are produced by\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>pneumoniae<\/jats:italic>\n                    were efficiently utilized by\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>aeruginosa<\/jats:italic>\n                    . In pH\u2010uncontrolled co\u2010cultures, the low pH triggered by\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>pneumoniae<\/jats:italic>\n                    assimilation of glucose and lactic acid production negatively affected the growth of both strains. Nevertheless, ammonia production improved significantly, and\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>aeruginosa<\/jats:italic>\n                    growth dominated at later growth stages. This study revealed unreported metabolic interactions of two important pathogenic microorganisms and shed new lights into pathophysiology of bacterial lung infection.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.16105","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T00:28:15Z","timestamp":1655339295000},"page":"4885-4898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Food web and metabolic interactions of the lung inhabitants\n                    <i>Streptococcus pneumoniae<\/i>\n                    and\n                    <i>Pseudomonas aeruginosa<\/i>"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1403-0855","authenticated-orcid":false,"given":"Wael","family":"Sabra","sequence":"first","affiliation":[{"name":"Faculty of Life Science Rheine\u2010Waal University of Applied Sciences  Kleve Germany"},{"name":"Institute of 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