{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:34:52Z","timestamp":1792730092855,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["ACIF\/2019\/214"],"award-info":[{"award-number":["ACIF\/2019\/214"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["AICO\/2020\/086"],"award-info":[{"award-number":["AICO\/2020\/086"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Microbiology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Iron participates as an essential cofactor in the biosynthesis of critical cellular components, including DNA, proteins and lipids. The ergosterol biosynthetic pathway, which is an important target of antifungal treatments, depends on iron in four enzymatic steps. Our results in the model yeast\n                    <jats:italic>Saccharomyces cerevisiae<\/jats:italic>\n                    show that the expression of ergosterol biosynthesis (\n                    <jats:italic>ERG<\/jats:italic>\n                    ) genes is tightly modulated by iron availability probably through the iron\u2010dependent variation of sterol and heme levels. Whereas the transcription factors Upc2 and Ecm22 are responsible for the activation of\n                    <jats:italic>ERG<\/jats:italic>\n                    genes upon iron deficiency, the heme\u2010dependent factor Hap1 triggers their Tup1\u2010mediated transcriptional repression. The combined regulation by both activating and repressing regulatory factors allows for the fine\u2010tuning of\n                    <jats:italic>ERG<\/jats:italic>\n                    transcript levels along the progress of iron deficiency, avoiding the accumulation of toxic sterol intermediates and enabling efficient adaptation to rapidly changing conditions. The lack of these regulatory factors leads to changes in the yeast sterol profile upon iron\u2010deficient conditions. Both environmental iron availability and specific regulatory factors should be considered in ergosterol antifungal treatments.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.16157","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T20:13:46Z","timestamp":1660335226000},"page":"5248-5260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Transcriptional regulation of ergosterol biosynthesis genes in response to iron deficiency"],"prefix":"10.1111","volume":"24","author":[{"given":"Tania","family":"Jord\u00e1","sequence":"first","affiliation":[{"name":"Departamento de Biotecnolog\u00eda, Instituto de Agroqu\u00edmica y Tecnolog\u00eda de Alimentos (IATA) Consejo Superior de Investigaciones Cient\u00edficas (CSIC)  Paterna Valencia 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