{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:57:17Z","timestamp":1793307437535,"version":"4.5.0"},"reference-count":66,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["FKZ 02WRS1377"],"award-info":[{"award-number":["FKZ 02WRS1377"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["431531292"],"award-info":[{"award-number":["431531292"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Microbiology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Antibiotics are essential for modern medicine, they are employed frequently in hospitals and, therefore, present in hospital wastewater. Even in concentrations, that are lower than the minimum inhibitory concentrations (MICs) of susceptible bacteria, antibiotics may exert an influence and select resistant bacteria, if they exceed the MSCs (minimal selective concentrations) of resistant strains. Here, we compare the MSCs of fluorescently labelled\n                    <jats:italic>Acinetobacter baylyi<\/jats:italic>\n                    strains harboring spontaneous resistance mutations or a resistance plasmid with antibiotic concentrations determined in hospital wastewater. Low MSCs in the \u03bcg\/L range were measured for the quinolone ciprofloxacin (17\u2009\u03bcg\/L) and for the carbapenem meropenem (30\u2009\u03bcg\/L). A 24\u2009h continuous analysis of hospital wastewater showed daily fluctuations of the concentrations of these antibiotics with distinctive peaks at 7\u20138\u2009p.m. and 5\u20136\u2009a.m. The meropenem concentrations were always above the MSC and MIC values of\n                    <jats:italic>A. baylyi<\/jats:italic>\n                    . In addition, the ciprofloxacin concentrations were in the range of the lowest MSC for about half the time. These results explain the abundance of strains with meropenem and ciprofloxacin resistance in hospital wastewater and drains.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.16206","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T10:25:26Z","timestamp":1662978326000},"page":"5721-5733","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Antibiotic concentrations in raw hospital wastewater surpass minimal selective and minimum inhibitory concentrations of resistant\n                    <i>Acinetobacter baylyi<\/i>\n                    strains"],"prefix":"10.1111","volume":"24","author":[{"given":"Dominik","family":"Schuster","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology, Immunology and Parasitology University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Axtmann","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Immunology and Parasitology University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Holstein","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Immunology and Parasitology University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Felder","sequence":"additional","affiliation":[{"name":"Institute for Hygiene and Public Health University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Voigt","sequence":"additional","affiliation":[{"name":"Institute for Hygiene and Public Health University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"F\u00e4rber","sequence":"additional","affiliation":[{"name":"Institute for Hygiene and Public Health University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Ciorba","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Immunology and Parasitology University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Szekat","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Immunology and Parasitology University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Schallenberg","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Immunology and Parasitology University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"B\u00f6ckmann","sequence":"additional","affiliation":[{"name":"Environmental Systems Analysis Eberhard Karls University of Tuebingen  Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Zarfl","sequence":"additional","affiliation":[{"name":"Environmental Systems Analysis Eberhard Karls University of Tuebingen  Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Neidh\u00f6fer","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Immunology and Parasitology University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kornelia","family":"Smalla","sequence":"additional","affiliation":[{"name":"Julius K\u00fchn\u2010Institut, Federal Research Centre for Cultivated Plants, Institute for Epidemiology and Pathogen Diagnostics  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Exner","sequence":"additional","affiliation":[{"name":"Institute for Hygiene and Public Health University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Bierbaum","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Immunology and Parasitology University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00049"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2319"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh910"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm070"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2016.06.228"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix893"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01295-14"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056090"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2021.133405"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.02486-0"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00732-07"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011147"},{"key":"e_1_2_7_14_1","first-page":"1","article-title":"Bootstrap methods: Another look at the Jackknife","volume":"1","author":"Efron B.","year":"1979","journal-title":"The Annals of Statistics"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2307\/2965703"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.530"},{"key":"e_1_2_7_17_1","unstructured":"EUCAST(2022)European committee on antimicrobial susceptibility testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 12.0 valid from 2022\u201001\u201001. [WWW document]. URLhttp:\/\/www.eucast.org."},{"key":"e_1_2_7_18_1","unstructured":"European Centre for Disease Prevention and Control(2020)Antimicrobial consumption in the EU\/EEA \u2013 Annual Epidemiological Report 2019. [WWW document]. URLhttps:\/\/www.ecdc.europa.eu\/en\/publications-data\/surveillance-antimicrobial-consumption-europe-2019."},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03074-14"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13469"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01686-17"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002158"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2008.01819.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2012.07.005"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/1574-6968.12284"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.98.1.281-288.1969"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2016.01.044"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176695"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.151339"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10646-017-1762-y"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix132"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41396-019-0483-z"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.04.029"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2018.01.154"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaj2191"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1897\/07-080.1"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.09.083"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2014.03.076"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2012.12.004"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2016.02.103"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2012.11.027"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsec\/fiy057"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00969-18"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2013.01.010"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2017.03.011"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-139-2-295"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00102-19"},{"key":"e_1_2_7_48_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2022"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2018.06.040"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.105733"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1159\/000238751"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.06422-11"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.140894"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2019.03.006"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.2166\/wst.2015.484"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-01176-w"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.14.6.829"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2008\/019471-0"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2017.06.018"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2012.04.055"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2018.12.013"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1071\/EN19115"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2019.125032"},{"key":"e_1_2_7_64_1","unstructured":"WHO(2017) Global priority list of antibiotic resistant bacteria to guide research discovery and development of new antibiotics. [WWW document]. URLhttps:\/\/www.who.int\/medicines\/publications\/WHO-PPL-Short_Summary_25Feb-ET_NM_WHO.pdf?ua=1."},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04059-1"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.15938"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00058-16"}],"container-title":["Environmental Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1462-2920.16206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1462-2920.16206","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/sfamjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1462-2920.16206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:33:47Z","timestamp":1761870827000},"score":1,"resource":{"primary":{"URL":"https:\/\/sfamjournals.onlinelibrary.wiley.com\/doi\/10.1111\/1462-2920.16206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,10]]},"references-count":66,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1111\/1462-2920.16206"],"URL":"https:\/\/doi.org\/10.1111\/1462-2920.16206","archive":["Portico"],"relation":{},"ISSN":["1462-2912","1462-2920"],"issn-type":[{"value":"1462-2912","type":"print"},{"value":"1462-2920","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,10]]},"assertion":[{"value":"2022-03-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}