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Due to insecticide resistance, there is an urgent need to develop alternative control strategies. In our previous work, we found\n                    <jats:italic>Pseudomonas fluorescens<\/jats:italic>\n                    PpR24 can orally infect and kill the insecticide\u2010resistant green\u2010peach aphid (\n                    <jats:italic>Myzus persicae<\/jats:italic>\n                    ). However, the genetic basis of the insecticidal capability of PpR24 remains unclear. Genome sequencing of PpR24 confirmed the presence of various insecticidal toxins such as Tc (toxin complexes), Rhs (rearrangement hotspot) elements, and other insect\u2010killing proteases. Upon aphids infection with PpR24, RNA\u2010Seq analysis revealed 193 aphid genes were differentially expressed with down\u2010regulation of 16 detoxification genes. 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This comprehensive host\u2013pathogen transcriptomic analysis provides novel insight into the molecular basis of bacteria\u2010mediated aphid mortality and the potential of PpR24 as an effective biocontrol agent.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.16604","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:24:43Z","timestamp":1712017483000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Multiple toxins and a protease contribute to the aphid\u2010killing ability of\n                    <i>Pseudomonas fluorescens<\/i>\n                    <scp>PpR24<\/scp>"],"prefix":"10.1111","volume":"26","author":[{"given":"Deepa","family":"Paliwal","sequence":"first","affiliation":[{"name":"School of Biological Sciences University of Reading  Reading 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