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In this study,\n                    <jats:italic>Acanthamoeba<\/jats:italic>\n                    \u2010associated bacterial communities (AAB) exhibited significantly higher multidrug resistance than sediment\u2010associated bacterial communities (SAB) in a polluted estuarine system. All isolated amoebae belonged to the T4 genotype, suggesting selection for resilient host organisms. AAB displayed elevated multiple antibiotic resistance (MAR) indices and increased resistance to multiple antibiotic classes, particularly aminoglycosides, macrolides, fluoroquinolones and \u03b2\u2010lactams. Correlation analysis revealed that resistance in AAB, but not SAB, was associated with potentially toxic elements (PTEs) known to influence phagocyte survival, including arsenic, vanadium, and calcium. These elements may select for traits that confer metal and antibiotic resistance. The findings support a model where protists act as selective environments for AMR, favoring bacteria that possess enhanced tolerance mechanisms. This work provides the first direct evidence linking PTE exposure to the intracellular resistome of\n                    <jats:italic>Acanthamoeba<\/jats:italic>\n                    \u2010associated bacteria. It underscores the need for AMR monitoring frameworks that include protist\u2010bacteria interactions, with implications for One Health and environmental risk assessment strategies. Moreover, this approach is scalable for application in low\/middle\u2010income countries, where AMR burden is greatest and surveillance capacity remains limited.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.70193","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T04:40:21Z","timestamp":1761799221000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Microbial Trojan Horse and Antimicrobial Resistance: Acanthamoeba as an Environmental Reservoir for Multidrug Resistant Bacteria"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2426-0600","authenticated-orcid":false,"given":"Ronnie","family":"Mooney","sequence":"first","affiliation":[{"name":"Department of Civil and Environmental Engineering University of Strathclyde  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9471-2130","authenticated-orcid":false,"given":"Erin","family":"Corbett","sequence":"additional","affiliation":[{"name":"Joint Nature Conservation Committee (JNCC) Inverdee House  Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6128-601X","authenticated-orcid":false,"given":"Elisa","family":"Giammarini","sequence":"additional","affiliation":[{"name":"School of Health and Life Sciences University of the West of Scotland  Paisley UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6934-6892","authenticated-orcid":false,"given":"Kiri","family":"Rodgers","sequence":"additional","affiliation":[{"name":"School of Health and Life Sciences University of the West of Scotland  Paisley UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5366-5922","authenticated-orcid":false,"given":"Carla","family":"Donet","sequence":"additional","affiliation":[{"name":"School of Health and Life Sciences University of the West of Scotland  Paisley UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1004-9532","authenticated-orcid":false,"given":"Ernest","family":"Mui","sequence":"additional","affiliation":[{"name":"School of Health and Life Sciences University of the West of Scotland  Paisley UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9956-6795","authenticated-orcid":false,"given":"Arhama T. 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