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The identification of the various detoxification strategies developed by fungi, and the molecular targets of these compounds is limited in Basidiomycetes because of the lack of genetic tools. To circumvent this problem, we have developed a direct genetic strategy in the white\u2010rot fungus\n                    <jats:italic>Phanerochaete chrysosporium<\/jats:italic>\n                    . A library of\n                    <jats:italic>P. chrysosporium<\/jats:italic>\n                    UV mutants was generated and screened to isolate mutants resistant to\n                    <jats:italic>Bagassa guianensis<\/jats:italic>\n                    wood extractives (BWE). Wood extractives contribute to\n                    <jats:italic>B. guianensis<\/jats:italic>\n                    wood durability, and resistance to those extractives confers to the mutants a better ability to mineralise wood sawdust. This resistance phenotype is due to causal mutation(s) in the gene coding for an ortholog of the human DENND6, a protein involved in endocytic recycling. Using in silico and in\u00a0vivo assays, we identified that moracin N, found in BWE, has antifungal activity likely by binding onto the wild type\n                    <jats:italic>Pc<\/jats:italic>\n                    DENND6 protein but not onto the mutated variant.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.70205","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T12:05:45Z","timestamp":1764849945000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unravelling Wood Extractive Resistance in\n                    <i>Phanerochaete chrysosporium<\/i>\n                    Through Random Mutagenesis"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7266-0217","authenticated-orcid":false,"given":"Delphine","family":"Noel","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Lorraine INRAE, IAM  Nancy 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Genotoul  Castanet\u2010Tolosan France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8781-8133","authenticated-orcid":false,"given":"Antonio","family":"Fernandez\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine INRAE, IAM  Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2670-5274","authenticated-orcid":false,"given":"Mathieu","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine INRAE, IAM  Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2228-4035","authenticated-orcid":false,"given":"Nadine","family":"Amusant","sequence":"additional","affiliation":[{"name":"CIRAD, UMR EcoFoG, AgroParisTech, CNRS, INRAE, Universit\u00e9 des Antilles, 12 Universit\u00e9 de Guyane  Kourou France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0699-9113","authenticated-orcid":false,"given":"Eric","family":"Gelhaye","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine INRAE, IAM  Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5149-0474","authenticated-orcid":false,"given":"M\u00e9lanie","family":"Morel\u2010Rouhier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine INRAE, IAM  Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0939-8639","authenticated-orcid":false,"given":"Rodnay","family":"Sormani","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine INRAE, IAM  Nancy 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