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We analysed 3303 genomes from dairy environments across 52 countries, creating the first genome\u2010resolved map of co\u2010occurring resistance determinants in this critical agricultural interface. Metal\/stress resistance genes were present at levels comparable to AMR genes (28.85% of isolates showed metal dominance), with arsenic (\n                    <jats:italic>arsB<\/jats:italic>\n                    : 42.6% prevalence) and copper\/silver systems (\n                    <jats:italic>silR<\/jats:italic>\n                    : 98% in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    <\/jats:styled-content>\n                    ) frequently co\u2010occurring with tetracycline (\n                    <jats:italic>tet<\/jats:italic>\n                    (38): 43%) and multidrug efflux determinants (\n                    <jats:italic>lmrS<\/jats:italic>\n                    : 43%). Statistical analysis of 29,299 gene pairs identified 523 significant associations (FDR &lt;\u20090.05), revealing genetic linkage between arsenic resistance and tetracycline\/multidrug efflux genes (Jaccard \u2265\u20090.98) in over 40% of isolates. Co\u2010occurrence burden varied ninefold across taxa, with\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                    <\/jats:styled-content>\n                    functioning as a super\u2010reservoir species. Functional network analysis revealed that arsenic and copper resistance families operate as genomic hubs connecting to multiple antimicrobial classes, demonstrating that metal exposure maintains entire resistance modules through genetic linkage. These findings establish that AMR control strategies focused solely on antibiotic stewardship are insufficient; effective resistance mitigation requires integrated management of environmental metal contamination in dairy production systems.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.70285","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T06:00:25Z","timestamp":1775109625000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Global Analysis of the Co\u2010Occurrence of Antimicrobial and Metal Resistance Genes in Bacterial Genomes From Dairy\u2010Isolated Pathogens"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3741-4402","authenticated-orcid":false,"given":"Arlen Carvalho de Oliveira","family":"Almeida","sequence":"first","affiliation":[{"name":"Center for Food Analysis (NAL), Technological Development Support Laboratory 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