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We performed a comprehensive analysis of the lipidome from the subsurface aquifer of the CO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010rich, cold\u2010water Geyser Andernach (Germany), using ultra\u2010high\u2010resolution mass spectrometry. We detected iGDGT\u20100, presumably derived from the dominant community member\n                    <jats:italic>Candidatus<\/jats:italic>\n                    Altiarchaeum, providing supporting evidence for its ability to synthesise tetraethers, as previously predicted from metagenomic data. Beyond the typical iGDGT\u20100 and acyclic glycerol trialkyl glycerol tetraether (iGTGT\u20100), we discovered novel structural derivatives, here referred to as extended iGDGTs and iGTGTs, characterised by the asymmetrical addition of up to two isoprenoid units to only one of their hydrocarbon side chains, analogous to those found in extended archaeols. The apparent absence of GDGT ring synthase A and B genes in the corresponding metagenome\u2010assembled genome raises the possibility that the producing archaea may utilise extended iGDGTs as a membrane adaptation to cope with the nutrient\u2010depleted conditions of the geyser environment, highlighting the adaptive flexibility of archaea to extreme physicochemical conditions.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.70286","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T08:20:03Z","timestamp":1773994803000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel Extended Tetraether Lipids Found in a High\u2010\n                    <scp>\n                      CO\n                      <sub>2<\/sub>\n                    <\/scp>\n                    Geyser"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4577-3532","authenticated-orcid":false,"given":"Janina","family":"Groninga","sequence":"first","affiliation":[{"name":"MARUM \u2010 Center for Marine Environmental Sciences University of Bremen  Bremen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9148-5945","authenticated-orcid":false,"given":"Leonie","family":"Wittig","sequence":"additional","affiliation":[{"name":"MARUM \u2010 Center for Marine Environmental Sciences University of Bremen  Bremen Germany"},{"name":"Faculty of Geosciences University of Bremen  Bremen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6600-7641","authenticated-orcid":false,"given":"Feriel","family":"Bouderka","sequence":"additional","affiliation":[{"name":"Environmental Metagenomics, Research Center One Health Ruhr of the University Alliance Ruhr University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3182-6596","authenticated-orcid":false,"given":"Till L. 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