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Here we provide preliminary evidence that rearing of the medicinal beetle\n                    <jats:italic>Blaps rhynchopetera<\/jats:italic>\n                    reshapes its gut microbiota and metabolome, beyond mere environmental effects. Metabolomic analysis revealed 727 significantly altered metabolites, with 436 compounds, many linked to analgesic and anti\u2010inflammatory activities, markedly reduced under rearing. Network pharmacology analysis suggested that this metabolic remodelling alters the overall regulatory landscape, with reduced network complexity compared to wild counterparts. Metagenomic profiling uncovered a decline in Pseudomonadota, a phylum positively correlated with multiple bioactive metabolites. Preliminary reintroduction of four Pseudomonadota strains suggested their potential involvement in terpenoid backbone biosynthesis, a key pathway for natural product synthesis. These findings reveal an intrinsic trade\u2010off between rearing\u2010driven microbial homogenization and preservation of medicinal potency, highlighting the need for microbiome\u2010informed rearing strategies.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.70304","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:55Z","timestamp":1776643255000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanisms Underlying Bioactive Compounds Decline in Medicinal\n                    <i>Blaps rhynchopetera<\/i>\n                    During Artificial Rearing"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8269-8870","authenticated-orcid":false,"given":"Xizhe","family":"Yang","sequence":"first","affiliation":[{"name":"Institute of Highland Forest Science Chinese Academy of Forestry  Kunming China"},{"name":"College of Forestry Nanjing 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Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), State Key Laboratory of Genetic Evolution and Animal Models, Sino\u2010African Joint Research Center, and New Cornerstone Science Laboratory Kunming..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9986-9950","authenticated-orcid":false,"given":"Qiumin","family":"Lv","sequence":"additional","affiliation":[{"name":"Engineering Laboratory of Peptides of Chinese Academy of Sciences, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ\u2010CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non\u2010Human Primates, National Research Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility), State Key Laboratory of Genetic Evolution and Animal Models, Sino\u2010African Joint Research Center, and New Cornerstone Science Laboratory 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