{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:50:15Z","timestamp":1782388215580,"version":"3.54.5"},"reference-count":118,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["546565602"],"award-info":[{"award-number":["546565602"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["459850971"],"award-info":[{"award-number":["459850971"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Microbiology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Diet influences animal health and their microbiomes, potentially affecting how they cope with environmental stressors such as rising temperatures and altered food quality associated with climate change. Using a multifactorial experiment, larvae of the frog\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Rana temporaria<\/jats:italic>\n                    <\/jats:styled-content>\n                    were reared on three diets differing in protein, fat, and animal\u2010derived components (low\u2010, intermediate\u2010, and high\u2010quality), at two temperatures (18\u00b0C and 24.5\u00b0C), and either exposed or not to a simulated heatwave (28\u00b0C for 48\u2009h). We examined how these treatments and associated shifts in gut bacterial indicators and predicted microbial metabolic pathways related to nutrient assimilation, host health (body condition and developmental rate), and escape behaviour. Larvae maintained body condition and developed faster at 24.5\u00b0C, with higher diet quality further accelerating development. An intermediate\u2010quality diet reduced responsiveness to an aversive stimulus at 24.5\u00b0C, although this effect disappeared following heatwave exposure. Heatwave conditions were associated with increased abundance of\n                    <jats:italic>Klebsiella<\/jats:italic>\n                    and a predicted increase in the myo\u2010inositol degradation pathway, which may influence membrane dynamics and signalling and may increase attention levels. Despite microbial shifts, host performance remained similar across most treatments, suggesting substantial microbiome plasticity and the presence of functionally redundant enterotypes that help buffer environmental stress.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.70331","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T04:41:33Z","timestamp":1779770493000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interplay of Diet, Heat Stress, and the Microbiome Shapes Health and Escape Behaviour in Amphibian Larvae"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1316-1255","authenticated-orcid":false,"given":"Paula C.","family":"Eterovick","sequence":"first","affiliation":[{"name":"Leibniz Institute DSMZ \u2010 German Collection of Microorganisms and Cell Cultures GmbH  Braunschweig Germany"},{"name":"Zoological Institute Technische Universit\u00e4t Braunschweig  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Glos","sequence":"additional","affiliation":[{"name":"Institute of Cell and System Biology Universit\u00e4t Hamburg  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Burkart","sequence":"additional","affiliation":[{"name":"Leibniz Institute DSMZ \u2010 German Collection of Microorganisms and Cell Cultures GmbH  Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Overmann","sequence":"additional","affiliation":[{"name":"Leibniz Institute DSMZ \u2010 German Collection of Microorganisms and Cell Cultures GmbH  Braunschweig Germany"},{"name":"SNSB\u00a0\u2013\u00a0Staatliche Naturwissenschaftliche Sammlungen Bayerns  M\u00fcnchen Germany"},{"name":"Chair of Molecular Biodiversity Research, Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  M\u00fcnchen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Ruthsatz","sequence":"additional","affiliation":[{"name":"Zoological Institute Technische Universit\u00e4t Braunschweig  Braunschweig Germany"},{"name":"Ecology, Evolution, and Development Group Department of Wetland Ecology, Do\u00f1ana\u00a0Biological Station  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.12017"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1755\u20100998.13014"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00442\u2010002\u20100876\u2010x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/694122"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021\u20109258(18)61857\u20105"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anbehav.2011.05.029"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/419764"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09944"},{"key":"e_1_2_11_10_1","unstructured":"Bastiani V. I. M.2023.Anuran Amphibians in Highland Grasslands in Southern Brazil: Effects of Habitat Degradation Sensitivity and Thermal Tolerance. PhD Dissertation Universidade Federal de Santa Maria Brazil."},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1139\/f07\u2010063"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102982.2012.01906.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168\u2010020\u201000875\u20100"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021\u20109258(18)96836\u20105"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021\u20109258(18)96837\u20107"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587\u2010019\u20100209\u20109"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44358\u2010025\u201000101\u20105"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2018.05.028"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btac438"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000080107"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ecy.1541"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1164"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1890\/13\u20100133.1"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238\u2010013\u20103017\u2010x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/2041\u2010210X.14115"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.100611"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1472\u20104642.2003.00012.x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201038"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20107345.2004.tb00113.x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.246735"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/phen.12064"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2015.02.021"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/beheco\/arx188"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02099\u201015"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587\u2010020\u20100548\u20106"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102486.2011.02518.x"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201070274\u2010w"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201022315\u20108"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.2139\/ssrn.4680902"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049\u20102618\u20102\u201015"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.186.10.3117\u20103123.2004"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42523\u2010023\u201000227\u2010x"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.245191"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41559\u2010022\u201001686\u20102"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1163\/15685381\u2010bja10020"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10021\u2010012\u20109524\u20104"},{"key":"e_1_2_11_47_1","first-page":"183","article-title":"A Simplified Table for Staging Anuran Embryos and Larvae With Notes on Identification","volume":"16","author":"Gosner K. L.","year":"1960","journal-title":"Herpetologica"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201076"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/brv.13081"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.040865"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.57.030195.000315"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.191550411"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201025"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.2307\/1934352"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00725"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.896348"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbx085"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10750\u2010023\u201005439\u20105"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/37.2.146"},{"key":"e_1_2_11_60_1","first-page":"1","volume-title":"Climate Change 2023: Synthesis Report. Contribution of Working Groups I, II and III to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change. Core Writing Team","author":"Lee H.","year":"2023"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/raq.12375"},{"key":"e_1_2_11_62_1","doi-asserted-by":"crossref","unstructured":"Lenth R.2017.Emmeans: Estimated Marginal Means Aka Least\u2010Squares Means. R Package Version 0.9.1.https:\/\/CRAN.R\u2010project.org\/package=emmeans.","DOI":"10.32614\/CRAN.package.emmeans"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10531\u2010022\u201002426\u20105"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41559\u2010018\u20100519\u20101"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.71.12.8228-8235.2005"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010023\u201006578\u20104"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay0240"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.3389\/fevo.2021.633160"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10531\u2010015\u20100940\u20106"},{"key":"e_1_2_11_70_1","volume-title":"Tadpoles: The Biology of Anuran Larvae","author":"McDiarmid R. W.","year":"1999"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1218525110"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061217"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0197256"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1080\/03949370.2020.1830859"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1098412"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1163\/15685381\u2010bja10153"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102435.2011.01866.x"},{"key":"e_1_2_11_78_1","doi-asserted-by":"crossref","unstructured":"Oksanen J. G.Simpson F.Blanchet et\u00a0al.2026.\u201cvegan: Community Ecology Package.\u201dhttps:\/\/doi.org\/10.32614\/CRAN.package.vegan.","DOI":"10.32614\/CRAN.package.vegan"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201060"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100706.2009.17643.x"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102435.2010.01751.x"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2020.0184"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1670\/13\u2010059"},{"key":"e_1_2_11_84_1","unstructured":"R Core Team.2024.R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing. Version 4.4.2.https:\/\/cran.r\u2010project.org\/."},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1890\/0012-9658(2001)082[0523:MABPOL]2.0.CO;2"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010earth\u2010050212\u2010123"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1093\/conphys\/coaa100"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1242\/bio.048041"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.04.011"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/ecy.1524"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb\u20102011\u201012\u20106\u2010r60"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095046"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.08.003"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009906107"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00025"},{"key":"e_1_2_11_96_1","unstructured":"Singmann H. B.Bolker J.Westfall F.Aust andM.Ben\u2010Shachar.2024._afex: Analysis of Factorial Experiments. doi:10.32614\/CRAN.package.afex<10.32614\/CRAN.package.afex> R Package Version 1.4\u20131.https:\/\/CRAN.R\u2010project.org\/package=afex."},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.4324\/9780429318405-2"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/lno.70012"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anbehav.2010.12.002"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1890\/14\u20100235.1"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1420\u20109101.2004.00790.x"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/1365\u20102656.12183"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/1365\u20102435.13752"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000196"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep39600"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2023.121774"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.202000004"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801921105"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.applanim.2015.09.006"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/29.1.65"},{"key":"e_1_2_11_111_1","volume-title":"The Ecology and Behavior of Amphibians","author":"Wells K. D.","year":"2019"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.01359"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.250837"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/brv.13017"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btad470"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.48479"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2017.121"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1111\/oik.07082"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.846336"}],"container-title":["Environmental Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/sfamjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1462-2920.70331","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/sfamjournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1462-2920.70331","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/sfamjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1462-2920.70331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:30:01Z","timestamp":1782387001000},"score":1,"resource":{"primary":{"URL":"https:\/\/sfamjournals.onlinelibrary.wiley.com\/doi\/10.1111\/1462-2920.70331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,25]]},"references-count":118,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/1462-2920.70331"],"URL":"https:\/\/doi.org\/10.1111\/1462-2920.70331","archive":["Portico"],"relation":{},"ISSN":["1462-2912","1462-2920"],"issn-type":[{"value":"1462-2912","type":"print"},{"value":"1462-2920","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,25]]},"assertion":[{"value":"2026-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70331"}}