{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:44:56Z","timestamp":1791989096781,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Microbiology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Gut microbiota and metabolites have been increasingly implicated in the pathogenesis of immune inflammation, which may be affected by environmental factors. This study aimed to explore the influence of co\u2010exposure to high humidity and temperatures (low, normal or high) on biomarkers of immune inflammation and potential mechanisms. We established C57BL\/6J mice models (with equal numbers of males and females) of high humidity and low temperature (HH\u2010LT), normal temperature (HH\u2010NT) or high temperature (HH\u2010HT) co\u2010exposure environments to observe the impact of high humidity and different temperature co\u2010exposure environments for 28 and 56 consecutive days. Following exposure, results showed that all six combined exposure conditions significantly increased pro\u2010inflammatory cytokines (TNF\u2010\u03b1, IL\u20101\u03b2, IL\u201012p70), decreased anti\u2010inflammatory cytokines (IL\u20104, IL\u201010) and elevated the Teff\/Treg ratio in the spleen. Gut microbiota analysis revealed reduced\n                    <jats:italic>Akkermansia<\/jats:italic>\n                    and increased\n                    <jats:italic>Desulfovibrio<\/jats:italic>\n                    and\n                    <jats:italic>Enterorhabdus<\/jats:italic>\n                    . Serum metabolomics identified widespread disturbances enriched in pathways including protein digestion and absorption, lysine degradation, phenylalanine metabolism and unsaturated fatty acid biosynthesis. Pearson correlation analysis confirmed significant associations among microbial shifts, immune\u2010inflammatory dysregulation and metabolic perturbations\u2014suggesting that high humidity combined with different temperatures correlated with immune imbalance, likely mediated by gut dysbiosis and serum metabolic disruption.\n                  <\/jats:p>","DOI":"10.1111\/1462-2920.70365","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:37:57Z","timestamp":1782819477000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immune\u2010Inflammatory Imbalance in Mice Under High Humidity and Three Different Ambient Temperatures: Insights From Gut Microbiome and Serum Metabolomics"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6972-3337","authenticated-orcid":false,"given":"Hua","family":"Yang","sequence":"first","affiliation":[{"name":"Department 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