{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:29:27Z","timestamp":1789558167125,"version":"build-2803163510"},"reference-count":66,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T00:00:00Z","timestamp":1695427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["213579"],"award-info":[{"award-number":["213579"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["220540\/Z\/20\/A"],"award-info":[{"award-number":["220540\/Z\/20\/A"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Sociology Health &amp; Illness"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This article explores how the meanings and values of diagnosis are being reconfigured at the interface between technological innovation and imaginaries of precision medicine. From genome sequencing to biological and digital \u2018markers\u2019 of disease, technological innovation occupies an increasingly central space in the way we imagine future health and illness. These imaginaries are usually centred on the promise of faster, more precise and personalised diagnosis, and the associated hope that if detected early enough disease can be effectively treated and prevented. Underpinning and reproduced through these narratives of the future is a re\u2010conceptualisation of diagnostic processes and categories around the anticipation of future risk, as noted by recent theoretical developments in the sociology of diagnosis and related disciplines. Adding to this literature, in this article we explore what makes these emerging diagnostic arrangements valuable, to whom and how. Drawing on interviews with experts involved in the development of digital biomarkers for Alzheimer\u2019s disease, we trace how multiple and at times conflicting applications of the tools, and the value(s) attached to them, are coproduced. We thus ask what possibilities are pursued, or foreclosed, through the work of imagining the future of diagnosis.<\/jats:p>","DOI":"10.1111\/1467-9566.13713","type":"journal-article","created":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T10:50:03Z","timestamp":1695466203000},"page":"261-278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Detecting value(s): Digital biomarkers for Alzheimer\u2019s disease and the valuation of new diagnostic technologies"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3761-9080","authenticated-orcid":false,"given":"Alessia","family":"Costa","sequence":"first","affiliation":[{"name":"Engagement and Society Wellcome Connecting Science Wellcome Genome Campus  Cambridgeshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Milne","sequence":"additional","affiliation":[{"name":"Engagement and Society Wellcome Connecting Science Wellcome Genome Campus  Cambridgeshire UK"},{"name":"Kavli Centre for Ethics, Science, and the Public Faculty of Education University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,23]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467\u20109566.ep10933329"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467\u20109566.2011.01438.x"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2019.112444"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467\u20109566.2011.01441.x"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20100009.2009.00563.x"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaging.2004.06.005"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1057\/biosoc.2013.6"},{"key":"e_1_2_13_9_1","volume-title":"Rationalizing medical work: Decision\u2010support techniques and medical practices","author":"Berg M.","year":"1997"},{"key":"e_1_2_13_10_1","first-page":"65","volume-title":"The Bloomsbury companion to contemporary philosophy of medicine","author":"Boenink M.","year":"2016"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1057\/s41292\u2010017\u20100065\u20100"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2011.04.022"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.2307\/j.ctv18b5d19"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1353\/con.2007.0019"},{"key":"e_1_2_13_15_1","volume-title":"Contested futures: A sociology of prospective techno\u2010science","author":"Brown N.","year":"2016"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0971721820960252"},{"key":"e_1_2_13_17_1","unstructured":"Department for Business Energy & Industrial Strategy. (2019).Press release: UK to innovate new life\u2010saving treatment and diagnosis technology.https:\/\/www.gov.uk\/government\/news\/uk\u2010to\u2010innovate\u2010new\u2010life\u2010saving\u2010treatment\u2010and\u2010diagnosis\u2010technology"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.2005.042770"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780199689583.001.0001"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/20539517221113775"},{"key":"e_1_2_13_21_1","volume-title":"Inclusion: The politics of difference in medical research","author":"Epstein S.","year":"2009"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467\u20109566.2011.01385.x"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2019.112553"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.17157\/mat.8.2.5085"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/17530350.2019.1684337"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467\u20109566.12257"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/gnv067"},{"key":"e_1_2_13_28_1","unstructured":"Holmes E.(2014).Theranos CEO TedMed talk.https:\/\/www.google.com\/search?q=elizabeth+holmes+ted+talk+transcript&rlz=1C5CHFA_enGB942GB942&oq=elizabeth+holmes+TEDTALK+tra&gs_lcrp=EgZjaHJvbWUqCQgBEAAYDRiABDIGCAAQRRg5MgkIARAAGA0YgAQyCggCEAAYhgMYigUyCggDEAAYhgMYigUyCggEEAAYhgMYigUyCggFEAAYhgMYigXSAQg4MTI3ajBqNKgCALACAA&sourceid=chrome&ie=UTF\u20108#fpstate=ive&vld=cid:33c70720 vid:SX7ec3uDlhs"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.004"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.7208\/chicago\/9780226276663.001.0001"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hast.614"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2011.07.014"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467\u20109566.13389"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.7765\/9781526141019"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0162243919866898"},{"key":"e_1_2_13_36_1","volume-title":"Preventing dementia?: Critical perspectives on a new paradigm of preparing for old age","author":"Leibing A.","year":"2021"},{"key":"e_1_2_13_37_1","volume-title":"The Alzheimer conundrum: Entanglements of dementia and aging","author":"Lock M.","year":"2016"},{"key":"e_1_2_13_38_1","volume-title":"The imperative of health: Public health and the regulated body","author":"Lupton D.","year":"1997"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1057\/sth.2013.10"},{"key":"e_1_2_13_40_1","volume-title":"Technoscientific imaginaries: Conversations, profiles, and memoirs","author":"Marcus G. E.","year":"1995"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/2053951720949567"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/20539517211070748"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467\u20109566.12731"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/14636778.2019.1683213"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.14361\/transcript.9783839414477"},{"key":"e_1_2_13_46_1","first-page":"119","volume-title":"Care in practice: On tinkering in clinics, homes and farms","author":"Moreira T.","year":"2015"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102019\u2010030279"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.0435"},{"key":"e_1_2_13_49_1","article-title":"Joseph Rago: A drop of blood. An instant diagnosis","author":"Rago B. J.","year":"2013","journal-title":"Wall Street Journal"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010publhealth\u2010040617\u2010014158"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.7208\/chicago\/9780226345192.001.0001"},{"key":"e_1_2_13_52_1","volume-title":"Medicine and the reign of technology","author":"Reiser S. J.","year":"1981"},{"key":"e_1_2_13_53_1","volume-title":"Diagnostic fluidity: Working with uncertainty and mutability","author":"Ris\u00f8r M. B.","year":"2018"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/30.3.427"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/1468\u20100009.t01\u20101\u201000003"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2021.113965"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(15)60248\u20103"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2011.06.030"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010021\u201002693\u2010x"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00921"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.17157\/mat.8.2.6516"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2017.05.017"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467\u20109566.13016"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-37177-7_13"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022146510386794"},{"key":"e_1_2_13_66_1","unstructured":"UK National Screening Committee. (2018).Screening for dementia: External review against programme appraisal criteria for the UK National Screening Committee. Retrieved November 2022 fromview-health-screening-recommendations.service.gov.uk\/dementia\/"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(22)00428\u20108"}],"container-title":["Sociology of Health &amp; Illness"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1467-9566.13713","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T03:13:53Z","timestamp":1710818033000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1467-9566.13713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,23]]},"references-count":66,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/1467-9566.13713"],"URL":"https:\/\/doi.org\/10.1111\/1467-9566.13713","archive":["Portico"],"relation":{},"ISSN":["0141-9889","1467-9566"],"issn-type":[{"value":"0141-9889","type":"print"},{"value":"1467-9566","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,23]]},"assertion":[{"value":"2023-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}