{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:02:47Z","timestamp":1792587767226,"version":"4.5.0"},"reference-count":74,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,11,29]],"date-time":"2014-11-29T00:00:00Z","timestamp":1417219200000},"content-version":"vor","delay-in-days":697,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Microbiology and Infection"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1111\/1469-0691.12056","type":"journal-article","created":{"date-parts":[[2012,10,3]],"date-time":"2012-10-03T10:33:09Z","timestamp":1349260389000},"page":"15-22","source":"Crossref","is-referenced-by-count":155,"title":["Next-generation sequencing technology in clinical virology"],"prefix":"10.1016","volume":"19","author":[{"given":"M.R.","family":"Capobianchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Giombini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Rozera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/1469-0691.12056_bib1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nrg2626","article-title":"Sequencing technologies\u2019the next generation","volume":"11","author":"Metzker","year":"2010","journal-title":"Nat Rev Genet"},{"key":"10.1111\/1469-0691.12056_bib2","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.nbt.2008.12.009","article-title":"Next-generation DNA sequencing techniques","volume":"25","author":"Ansorge","year":"2009","journal-title":"N Biotechnol"},{"key":"10.1111\/1469-0691.12056_bib3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jgg.2011.02.003","article-title":"The impact of next-generation sequencing on genomics","volume":"38","author":"Zhang","year":"2011","journal-title":"J Genet Genomics"},{"key":"10.1111\/1469-0691.12056_bib4","first-page":"2881","article-title":"Comparison of next-generation sequencing systems","volume":"50","author":"Liu","year":"2012","journal-title":"J Biomed Biotechnol"},{"key":"10.1111\/1469-0691.12056_bib5","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1586\/erm.11.3","article-title":"Next-generation sequencing and its applications in molecular diagnostics","volume":"11","author":"Su","year":"2011","journal-title":"Expert Rev Mol Diagn"},{"key":"10.1111\/1469-0691.12056_bib6","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s13353-011-0057-x","article-title":"Sequencing technologies and genome sequencing","volume":"52","author":"Pareek","year":"2011","journal-title":"J Appl Genet"},{"key":"10.1111\/1469-0691.12056_bib7","doi-asserted-by":"crossref","first-page":"7861","DOI":"10.3390\/ijms12117861","article-title":"Applications of next-generation sequencing technologies to diagnostic virology","volume":"12","author":"Barzon","year":"2011","journal-title":"Int J Mol Sci"},{"key":"10.1111\/1469-0691.12056_bib8","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1099\/vir.0.043182-0","article-title":"Application of next-generation sequencing technologies in virology","volume":"93","author":"Radford","year":"2012","journal-title":"J Gen Virol"},{"key":"10.1111\/1469-0691.12056_bib9","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1053\/j.gastro.2012.02.027","article-title":"New virologic tools for management of chronic hepatitis B and C","volume":"142","author":"Chevaliez","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1111\/1469-0691.12056_bib10","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.coviro.2011.07.006","article-title":"From orphan virus to pathogen: the path to the clinical lab","volume":"1","author":"Li","year":"2011","journal-title":"Curr Opin Virol"},{"key":"10.1111\/1469-0691.12056_bib11","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.tvjl.2010.10.014","article-title":"Metagenomics and the molecular identification of novel viruses","volume":"190","author":"Bexfield","year":"2011","journal-title":"Vet J"},{"key":"10.1111\/1469-0691.12056_bib12","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1056\/NEJMoa073785","article-title":"A new arenavirus in a cluster of fatal transplant-associated diseases","volume":"358","author":"Palacios","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1111\/1469-0691.12056_bib13","doi-asserted-by":"crossref","first-page":"e1000212","DOI":"10.1371\/journal.ppat.1000212","article-title":"Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda","volume":"4","author":"Towner","year":"2008","journal-title":"PLoS Pathog"},{"key":"10.1111\/1469-0691.12056_bib14","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1126\/science.1146498","article-title":"A metagenomic survey of microbes in honey bee colony collapse disorder","volume":"318","author":"Cox-Foster","year":"2007","journal-title":"Science"},{"key":"10.1111\/1469-0691.12056_bib15","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.envint.2012.02.009","article-title":"Application of enteric viruses for fecal pollution source tracking in environmental waters","volume":"45","author":"Wong","year":"2012","journal-title":"Environ Int"},{"key":"10.1111\/1469-0691.12056_bib16","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1472-765X.2011.03014.x","article-title":"Viral metagenome analysis to guide human pathogen monitoring in environmental samples","volume":"52","author":"Bibby","year":"2011","journal-title":"Lett Appl Microbiol"},{"key":"10.1111\/1469-0691.12056_bib17","doi-asserted-by":"crossref","first-page":"4620","DOI":"10.1128\/JVI.06671-11","article-title":"Metagenomic analysis of viruses from bat fecal samples reveals many novel viruses in insectivorous bats in China","volume":"86","author":"Ge","year":"2012","journal-title":"J Virol"},{"key":"10.1111\/1469-0691.12056_bib18","doi-asserted-by":"crossref","first-page":"e4219","DOI":"10.1371\/journal.pone.0004219","article-title":"Direct metagenomic detection of viral pathogens in nasal and fecal specimens using an unbiased high-throughput sequencing approach","volume":"4","author":"Nakamura","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1111\/1469-0691.12056_bib19","doi-asserted-by":"crossref","first-page":"e16118","DOI":"10.1371\/journal.pone.0016118","article-title":"A sensitive assay for virus discovery in respiratory clinical samples","volume":"6","author":"de Vries","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1111\/1469-0691.12056_bib20","doi-asserted-by":"crossref","first-page":"e1485","DOI":"10.1371\/journal.pntd.0001485","article-title":"Virus identification in unknown tropical febrile illness cases using deep sequencing","volume":"6","author":"Yozwiak","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1111\/1469-0691.12056_bib21","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.chom.2010.05.006","article-title":"Merkel cell polyomavirus and two previously unknown polyomaviruses are chronically shed from human skin","volume":"7","author":"Schowalter","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1111\/1469-0691.12056_bib22","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1128\/JCM.01142-12","article-title":"Field monitoring of avian influenza viruses: whole genome sequencing and tracking of neuraminidase evolution using 454 pyrosequencing","volume":"50","author":"Croville","year":"2012","journal-title":"J Clin Microbiol"},{"key":"10.1111\/1469-0691.12056_bib23","first-page":"391","article-title":"Assembly and characterization of pandemic influenza A H1N1 genome in nasopharyngeal swabs using high-throughput pyrosequencing","volume":"34","author":"Bartolini","year":"2011","journal-title":"N Microbiol"},{"key":"10.1111\/1469-0691.12056_bib24","doi-asserted-by":"crossref","first-page":"e10256","DOI":"10.1371\/journal.pone.0010256","article-title":"Characterization of quasispecies of pandemic 2009 influenza A virus (A\/H1N1\/2009) by de novo sequencing using a next-generation DNA sequencer","volume":"5","author":"Kuroda","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1111\/1469-0691.12056_bib25","doi-asserted-by":"crossref","first-page":"e13381","DOI":"10.1371\/journal.pone.0013381","article-title":"A metagenomic analysis of pandemic influenza A (2009 H1N1) infection in patients from North America","volume":"5","author":"Greninger","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1111\/1469-0691.12056_bib26","doi-asserted-by":"crossref","first-page":"e19075","DOI":"10.1371\/journal.pone.0019075","article-title":"A comprehensive deep sequencing strategy for full-length genomes of influenza A","volume":"6","author":"Hoper","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1111\/1469-0691.12056_bib27","doi-asserted-by":"crossref","first-page":"e13564","DOI":"10.1371\/journal.pone.0013564","article-title":"Development of a low bias method for characterizing viral populations using next generation sequencing technology","volume":"5","author":"Willerth","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1111\/1469-0691.12056_bib28","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1089\/aid.2009.0083","article-title":"Use of massive parallel pyrosequencing for near full-length characterization of a unique HIV type 1 BF recombinant associated with a fatal primary infection","volume":"25","author":"Bruselles","year":"2009","journal-title":"AIDS Res Hum Retroviruses"},{"key":"10.1111\/1469-0691.12056_bib29","doi-asserted-by":"crossref","first-page":"5303","DOI":"10.1128\/JVI.00312-10","article-title":"Sequence variability in clinical and laboratory isolates of herpes simplex virus 1 reveals new mutations","volume":"84","author":"Szpara","year":"2010","journal-title":"J Virol"},{"key":"10.1111\/1469-0691.12056_bib30","doi-asserted-by":"crossref","first-page":"e36939","DOI":"10.1371\/journal.pone.0036939","article-title":"Genomic sequencing and comparative analysis of Epstein\u2013Barr virus genome isolated from primary nasopharyngeal carcinoma biopsy","volume":"7","author":"Kwok","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1111\/1469-0691.12056_bib31","doi-asserted-by":"crossref","first-page":"12980","DOI":"10.1073\/pnas.1117201109","article-title":"A quantitative quasispecies theory-based model of virus escape mutation under immune selection","volume":"109","author":"Woo","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/1469-0691.12056_bib32","article-title":"Detection of hemagglutinin 222 polymorphisms in influenza A(H1N1)PDM09-infected patients by ultra-deep pyrosequencing","author":"Selleri","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"10.1111\/1469-0691.12056_bib33","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1126\/scitranslmed.3000544","article-title":"Rapid emergence of protease inhibitor resistance in hepatitis C virus","volume":"2","author":"Rong","year":"2010","journal-title":"Sci Transl Med"},{"key":"10.1111\/1469-0691.12056_bib34","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1128\/JCM.05842-11","article-title":"Specific detection of naturally occurring hepatitis C virus mutants with resistance to telaprevir and boceprevir (protease inhibitors) among treatment-naive infected individuals","volume":"50","author":"Fonseca-Coronado","year":"2012","journal-title":"J Clin Microbiol"},{"key":"10.1111\/1469-0691.12056_bib35","doi-asserted-by":"crossref","first-page":"e24907","DOI":"10.1371\/journal.pone.0024907","article-title":"Genetic heterogeneity of hepatitis C virus in association with antiviral therapy determined by ultra-deep sequencing","volume":"6","author":"Nasu","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1111\/1469-0691.12056_bib36","doi-asserted-by":"crossref","first-page":"3952","DOI":"10.1128\/JVI.06627-11","article-title":"Analysis of hepatitis C virus intrahost diversity across the coding region by ultradeep pyrosequencing","volume":"86","author":"Lauck","year":"2012","journal-title":"J Virol"},{"key":"10.1111\/1469-0691.12056_bib37","doi-asserted-by":"crossref","first-page":"20509","DOI":"10.1073\/pnas.1105797108","article-title":"Contribution of a mutational bias in hepatitis Cvirus replication to the genetic barrier in the development of drug resistance","volume":"108","author":"Powdrill","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/1469-0691.12056_bib38","doi-asserted-by":"crossref","first-page":"11124","DOI":"10.1128\/JVI.01217-10","article-title":"Tracking the evolution of multiple in vitro hepatitis C virus replicon variants under protease inhibitor selection pressure by 454 deep sequencing","volume":"84","author":"Verbinnen","year":"2010","journal-title":"J Virol"},{"key":"10.1111\/1469-0691.12056_bib39","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/hep.24460","article-title":"Rapid emergence of telaprevir resistant hepatitis C virus strain from wildtype clone in vivo","volume":"54","author":"Hiraga","year":"2011","journal-title":"Hepatology"},{"key":"10.1111\/1469-0691.12056_bib40","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s00705-012-1230-1","article-title":"Analysis of the PKR-eIF2alpha phosphorylation homology domain (PePHD) of hepatitis C virus genotype 1 in HIV-coinfected patients by ultra-deep pyrosequencing and its relationship to responses to pegylated interferon-ribavirin treatment","volume":"157","author":"Bolcic","year":"2012","journal-title":"Arch Virol"},{"key":"10.1111\/1469-0691.12056_bib41","doi-asserted-by":"crossref","first-page":"e1002243","DOI":"10.1371\/journal.ppat.1002243","article-title":"Sequential bottlenecks drive viral evolution in early acute hepatitis C virus infection","volume":"7","author":"Bull","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1111\/1469-0691.12056_bib42","doi-asserted-by":"crossref","first-page":"6218","DOI":"10.1128\/JVI.02271-09","article-title":"Hepatitis C virus transmission bottlenecks analyzed by deep sequencing","volume":"84","author":"Wang","year":"2010","journal-title":"J Virol"},{"key":"10.1111\/1469-0691.12056_bib43","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/hep.24076","article-title":"Effect of immune pressure on hepatitis C virus evolution: insights from a single-source outbreak","volume":"53","author":"Merani","year":"2011","journal-title":"Hepatology"},{"key":"10.1111\/1469-0691.12056_bib44","doi-asserted-by":"crossref","first-page":"6369","DOI":"10.1128\/JVI.02204-10","article-title":"Temporal variations in the hepatitis C virus intrahost population during chronic infection","volume":"85","author":"Ramachandran","year":"2011","journal-title":"J Virol"},{"key":"10.1111\/1469-0691.12056_bib45","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1128\/JCM.00005-12","article-title":"Identification of hepatitis C virus transmission using a next-generation sequencing approach","volume":"50","author":"Escobar-Gutierrez","year":"2012","journal-title":"J Clin Microbiol"},{"key":"10.1111\/1469-0691.12056_bib46","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1101\/gr.6468307","article-title":"Characterization of mutation spectra with ultra-deep pyrosequencing: application to HIV-1 drug resistance","volume":"17","author":"Wang","year":"2007","journal-title":"Genome Res"},{"key":"10.1111\/1469-0691.12056_bib47","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1093\/nar\/gkm435","article-title":"DNA bar coding and pyrosequencing to identify rare HIV drug resistance mutations","volume":"35","author":"Hoffmann","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"10.1111\/1469-0691.12056_bib48","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1086\/596736","article-title":"Low-abundance drug-resistant viral variants in chronically HIV-infected, antiretroviral treatment-naive patients significantly impact treatment outcomes","volume":"199","author":"Simen","year":"2009","journal-title":"J Infect Dis"},{"key":"10.1111\/1469-0691.12056_bib49","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1086\/595703","article-title":"Minority quasispecies of drug-resistant HIV-1 that lead to early therapy failure in treatment-naive and -adherent patients","volume":"48","author":"Metzner","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.1111\/1469-0691.12056_bib50","doi-asserted-by":"crossref","first-page":"e158","DOI":"10.1371\/journal.pmed.0050158","article-title":"Minority HIV-1 drug resistance mutations are present in antiretroviral treatment-naive populations and associate with reduced treatment efficacy","volume":"5","author":"Johnson","year":"2008","journal-title":"PLoS Med"},{"key":"10.1111\/1469-0691.12056_bib51","doi-asserted-by":"crossref","first-page":"e19461","DOI":"10.1371\/journal.pone.0019461","article-title":"Added value of deep sequencing relative to population sequencing in heavily pre-treated HIV-1-infected subjects","volume":"6","author":"Codoner","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1111\/1469-0691.12056_bib52","doi-asserted-by":"crossref","first-page":"e6079","DOI":"10.1371\/journal.pone.0006079","article-title":"Low-abundance HIV drug-resistant viral variants in treatment-experienced persons correlate with historical antiretroviral use","volume":"4","author":"Le","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1111\/1469-0691.12056_bib53","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/QAI.0b013e3181bca669","article-title":"Minority variants associated with transmitted and acquired HIV-1 nonnucleoside reverse transcriptase inhibitor resistance: implications for the use of second-generation nonnucleoside reverse transcriptase inhibitors","volume":"52","author":"Varghese","year":"2009","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1111\/1469-0691.12056_bib54","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1097\/QAD.0b013e32834b34de","article-title":"Switching between raltegravir resistance pathways analyzed by deep sequencing","volume":"25","author":"Mukherjee","year":"2011","journal-title":"AIDS"},{"key":"10.1111\/1469-0691.12056_bib55","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1093\/jac\/dkr354","article-title":"\u2018Sentinel\u2019 mutations in standard population sequencing can predict the presence of HIV-1 reverse transcriptase major mutations detectable only by ultra-deep pyrosequencing","volume":"66","author":"Alteri","year":"2011","journal-title":"J Antimicrob Chemother"},{"key":"10.1111\/1469-0691.12056_bib56","doi-asserted-by":"crossref","first-page":"8359","DOI":"10.1128\/JVI.02582-10","article-title":"Detection of minority resistance during early HIV-1 infection: natural variation and spurious detection rather than transmission and evolution of multiple viral variants","volume":"85","author":"Gianella","year":"2011","journal-title":"J Virol"},{"key":"10.1111\/1469-0691.12056_bib57","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/infdis\/jiq030","article-title":"Deep sequencing to infer HIV-1 co-receptor usage: application to three clinical trials of maraviroc in treatment-experienced patients","volume":"203","author":"Swenson","year":"2011","journal-title":"J Infect Dis"},{"key":"10.1111\/1469-0691.12056_bib58","doi-asserted-by":"crossref","first-page":"e1002106","DOI":"10.1371\/journal.ppat.1002106","article-title":"Detection of inferred CCR5- and CXCR4-using HIV-1 variants and evolutionary intermediates using ultra-deep pyrosequencing","volume":"7","author":"Bunnik","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1111\/1469-0691.12056_bib59","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1093\/infdis\/jir427","article-title":"Deep sequencing of plasma and proviral HIV-1 to establish coreceptor usage: what is the clinical impact of the quasi species distribution?","volume":"204","author":"Abbate","year":"2011","journal-title":"J Infect Dis"},{"key":"10.1111\/1469-0691.12056_bib60","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1097\/QAD.0b013e32832b4399","article-title":"Detection of low-frequency pretherapy chemokine (CXC motif) receptor 4 (CXCR4)-using HIV-1 with ultra-deep pyrosequencing","volume":"23","author":"Archer","year":"2009","journal-title":"AIDS"},{"key":"10.1111\/1469-0691.12056_bib61","doi-asserted-by":"crossref","first-page":"e5683","DOI":"10.1371\/journal.pone.0005683","article-title":"Quantitative deep sequencing reveals dynamic HIV-1 escape and large population shifts during CCR5 antagonist therapy in vivo","volume":"4","author":"Tsibris","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1111\/1469-0691.12056_bib62","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1469-0691.2010.03350.x","article-title":"Analysis of co-receptor usage of circulating viral and proviral HIV genome quasi-species by ultra-deep pyrosequencing in patients who are candidates for CCR5 antagonist treatment","volume":"17","author":"Abbate","year":"2011","journal-title":"Clin Microbiol Infect"},{"key":"10.1111\/1469-0691.12056_bib63","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1742-4690-6-15","article-title":"Massively parallel pyrosequencing highlights minority variants in the HIV-1 env quasispecies deriving from lymphomonocyte sub-populations","volume":"6","author":"Rozera","year":"2009","journal-title":"Retrovirology"},{"key":"10.1111\/1469-0691.12056_bib64","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1097\/QAD.0b013e32832fd2e1","article-title":"Archived HIV-1 minority variants detected by ultra-deep pyrosequencing in provirus may be fully replication competent","volume":"23","author":"Rozera","year":"2009","journal-title":"AIDS"},{"key":"10.1111\/1469-0691.12056_bib65","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/jmv.23292","article-title":"Ultra-deep sequencing reveals hidden HIV-1 minority lineages and shifts of viral population between the cellular reservoirs of the infection after therapy interruption","volume":"84","author":"Rozera","year":"2012","journal-title":"J Med Virol"},{"key":"10.1111\/1469-0691.12056_bib66","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/QAD.0b013e328343489e","article-title":"Detection of quasispecies variants predicted to use CXCR4 by ultra-deep pyrosequencing during early HIV infection","volume":"25","author":"Abbate","year":"2011","journal-title":"AIDS"},{"key":"10.1111\/1469-0691.12056_bib67","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1093\/cid\/cir725","article-title":"Characterization of human immunodeficiency virus type 1 (HIV-1) diversity and tropism in 145 patients with primary HIV-1 infection","volume":"53","author":"Rieder","year":"2011","journal-title":"Clin Infect Dis"},{"key":"10.1111\/1469-0691.12056_bib68","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1128\/JVI.02011-08","article-title":"Use of massively parallel ultradeep pyrosequencing to characterize the genetic diversity of hepatitis B virus in drug-resistant and drug-naive patients and to detect minor variants in reverse transcriptase and hepatitis BS antigen","volume":"83","author":"Solmone","year":"2009","journal-title":"J Virol"},{"key":"10.1111\/1469-0691.12056_bib69","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1086\/597808","article-title":"Ultra-deep pyrosequencing of hepatitis B virus quasispecies from nucleoside and nucleotide reverse-transcriptase inhibitor (NRTI)-treated patients and NRTI-naive patients","volume":"199","author":"Margeridon-Thermet","year":"2009","journal-title":"J Infect Dis"},{"key":"10.1111\/1469-0691.12056_bib70","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1128\/AAC.00130-09","article-title":"Ultrasensitive genotypic detection of antiviral resistance in hepatitis B virus clinical isolates","volume":"53","author":"Fang","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1111\/1469-0691.12056_bib71","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1086\/647991","article-title":"Low-abundance drug resistance mutations: extending the HIV paradigm to hepatitis B virus","volume":"200","author":"Menzo","year":"2009","journal-title":"J Infect Dis"},{"key":"10.1111\/1469-0691.12056_bib72","doi-asserted-by":"crossref","first-page":"e35052","DOI":"10.1371\/journal.pone.0035052","article-title":"Dynamics of hepatitis B virus quasispecies in association with nucleos(t)ide analogue treatment determined by ultra-deep sequencing","volume":"7","author":"Nishijima","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1111\/1469-0691.12056_bib73","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/hep.25592","article-title":"Impact of hepatitis B virus (HBV) preS\/S genomic variability on HBV surface antigen and HBV DNA serum levels","volume":"56","author":"Pollicino","year":"2012","journal-title":"Hepatology"},{"key":"10.1111\/1469-0691.12056_bib74","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/1471-2164-12-245","article-title":"Accuracy and quality assessment of 454 GS-FLX Titanium pyrosequencing","volume":"12","author":"Gilles","year":"2011","journal-title":"BMC Genomics"}],"container-title":["Clinical Microbiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X14603049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X14603049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T11:14:28Z","timestamp":1562238868000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1198743X14603049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":74,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S1198743X14603049"],"URL":"https:\/\/doi.org\/10.1111\/1469-0691.12056","relation":{},"ISSN":["1198-743X"],"issn-type":[{"value":"1198-743X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}