{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:15:29Z","timestamp":1792181729213,"version":"4.4.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Microbiology and Infection"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1111\/1469-0691.12553","type":"journal-article","created":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T09:19:11Z","timestamp":1390295951000},"page":"110-117","source":"Crossref","is-referenced-by-count":73,"special_numbering":"S5","title":["A Phase 1 clinical trial of Hantaan virus and Puumala virus M-segment DNA vaccines for haemorrhagic fever with renal syndrome delivered by intramuscular electroporation"],"prefix":"10.1016","volume":"20","author":[{"given":"J.W.","family":"Hooper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.E.","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.M.","family":"Paolino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Newcomer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.E.","family":"McLain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Josleyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Hannaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Schmaljohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/1469-0691.12553_bib1","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.3201\/eid1608.090470","article-title":"Hantavirus infections in humans and animals, China","volume":"16","author":"Zhang","year":"2010","journal-title":"Emerg Infect Dis"},{"key":"10.1111\/1469-0691.12553_bib2","doi-asserted-by":"crossref","first-page":"e35996","DOI":"10.1371\/journal.pone.0035996","article-title":"DNA vaccine-generated duck polyclonal antibodies as a postexposure prophylactic to prevent hantavirus pulmonary syndrome (HPS)","volume":"7","author":"Brocato","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1111\/1469-0691.12553_bib3","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1128\/JVI.01822-07","article-title":"Immune serum produced by DNA vaccination protects hamsters against lethal respiratory challenge with Andes virus","volume":"82","author":"Hooper","year":"2008","journal-title":"J Virol"},{"key":"10.1111\/1469-0691.12553_bib4","doi-asserted-by":"crossref","first-page":"9894","DOI":"10.1128\/JVI.77.18.9894-9905.2003","article-title":"Active and passive vaccination against hantavirus pulmonary syndrome with Andes virus M genome segment-based DNA vaccine","volume":"77","author":"Custer","year":"2003","journal-title":"J Virol"},{"key":"10.1111\/1469-0691.12553_bib5","doi-asserted-by":"crossref","first-page":"8469","DOI":"10.1128\/JVI.75.18.8469-8477.2001","article-title":"DNA vaccination with the Hantaan virus M gene protects Hamsters against three of four HFRS hantaviruses and elicits a high-titer neutralizing antibody response in Rhesus monkeys","volume":"75","author":"Hooper","year":"2001","journal-title":"J Virol"},{"key":"10.1111\/1469-0691.12553_bib6","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1006\/viro.1998.9586","article-title":"DNA vaccination with hantavirus M segment elicits neutralizing antibodies and protects against seoul virus infection","volume":"255","author":"Hooper","year":"1999","journal-title":"Virology"},{"key":"10.1111\/1469-0691.12553_bib7","doi-asserted-by":"crossref","first-page":"5177","DOI":"10.1016\/j.vaccine.2008.03.097","article-title":"Mixing of M segment DNA vaccines to Hantaan virus and Puumala virus reduces their immunogenicity in hamsters","volume":"26","author":"Spik","year":"2008","journal-title":"Vaccine"},{"key":"10.1111\/1469-0691.12553_bib8","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/j.vaccine.2012.01.024","article-title":"A Phase 1 clinical trial of Hantaan virus and Puumala virus M-segment DNA vaccines for hemorrhagic fever with renal syndrome","volume":"30","author":"Boudreau","year":"2012","journal-title":"Vaccine"},{"key":"10.1111\/1469-0691.12553_bib9","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.4161\/hv.21873","article-title":"A multiagent filovirus DNA vaccine delivered by intramuscular electroporation completely protects mice from Ebola and Marburg virus challenge","volume":"8","author":"Grant-Klein","year":"2012","journal-title":"Hum Vaccin Immunother"},{"key":"10.1111\/1469-0691.12553_bib10","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1128\/CVI.00030-11","article-title":"A DNA vaccine for Venezuelan equine encephalitis virus delivered by intramuscular electroporation elicits high levels of neutralizing antibodies in multiple animal models and provides protective immunity to mice and nonhuman primates","volume":"18","author":"Dupuy","year":"2011","journal-title":"Clin Vaccine Immunol"},{"key":"10.1111\/1469-0691.12553_bib11","doi-asserted-by":"crossref","first-page":"7345","DOI":"10.1016\/j.vaccine.2010.09.005","article-title":"Immunogenicity and protective efficacy of a DNA vaccine against Venezuelan equine encephalitis virus aerosol challenge in nonhuman primates","volume":"28","author":"Dupuy","year":"2010","journal-title":"Vaccine"},{"key":"10.1111\/1469-0691.12553_bib12","doi-asserted-by":"crossref","first-page":"9563","DOI":"10.1128\/JVI.71.12.9563-9569.1997","article-title":"Naked DNA vaccines expressing the prM and E genes of Russian spring summer encephalitis virus and Central European encephalitis virus protect mice from homologous and heterologous challenge","volume":"71","author":"Schmaljohn","year":"1997","journal-title":"J Virol"},{"key":"10.1111\/1469-0691.12553_bib13","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1128\/CVI.00546-12","article-title":"Construction and nonclinical testing of a Puumala virus synthetic M gene-based DNA vaccine","volume":"20","author":"Brocato","year":"2013","journal-title":"Clin Vaccine Immunol"},{"key":"10.1111\/1469-0691.12553_bib14","doi-asserted-by":"crossref","first-page":"6728","DOI":"10.1016\/j.vaccine.2010.12.053","article-title":"Development and application of a flow cytometric potency assay for DNA vaccines","volume":"29","author":"Badger","year":"2011","journal-title":"Vaccine"},{"key":"10.1111\/1469-0691.12553_bib15","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1006\/viro.1994.1022","article-title":"Serological relationships among viruses in the Hantavirus genus, family Bunyaviridae","volume":"198","author":"Chu","year":"1994","journal-title":"Virology"},{"key":"10.1111\/1469-0691.12553_bib16","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1126\/science.2858126","article-title":"Antigenic and genetic properties of viruses linked to hemorrhagic fever with renal syndrome","volume":"227","author":"Schmaljohn","year":"1985","journal-title":"Science"},{"key":"10.1111\/1469-0691.12553_bib17","doi-asserted-by":"crossref","first-page":"6417","DOI":"10.1128\/JVI.69.10.6417-6423.1995","article-title":"A vaccinia virus-vectored Hantaan virus vaccine protects hamsters from challenge with Hantaan and Seoul viruses but not Puumala virus","volume":"69","author":"Chu","year":"1995","journal-title":"J Virol"},{"key":"10.1111\/1469-0691.12553_bib18","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2174\/1389200211314030004","article-title":"Electroporation in DNA vaccination protocols against cancer","volume":"14","author":"Chiarella","year":"2013","journal-title":"Curr Drug Metab"},{"key":"10.1111\/1469-0691.12553_bib19","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2174\/1389200211314030003","article-title":"In vivo DNA electrotransfer for immunotherapy of cancer and neurodegenerative diseases","volume":"14","author":"Fioretti","year":"2013","journal-title":"Curr Drug Metab"},{"key":"10.1111\/1469-0691.12553_bib20","doi-asserted-by":"crossref","first-page":"447","DOI":"10.2174\/156652311798192860","article-title":"Plasmid DNA gene therapy by electroporation: principles and recent advances","volume":"11","author":"Murakami","year":"2011","journal-title":"Curr Gene Ther"},{"key":"10.1111\/1469-0691.12553_bib21","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.coi.2011.03.008","article-title":"Electroporation delivery of DNA vaccines: prospects for success","volume":"23","author":"Sardesai","year":"2011","journal-title":"Curr Opin Immunol"},{"key":"10.1111\/1469-0691.12553_bib22","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1128\/JVI.64.7.3162-3170.1990","article-title":"Antigenic subunits of Hantaan virus expressed by baculovirus and vaccinia virus recombinants","volume":"64","author":"Schmaljohn","year":"1990","journal-title":"J Virol"}],"container-title":["Clinical Microbiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X14601841?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X14601841?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T07:01:17Z","timestamp":1597388477000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1198743X14601841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":22,"alternative-id":["S1198743X14601841"],"URL":"https:\/\/doi.org\/10.1111\/1469-0691.12553","relation":{},"ISSN":["1198-743X"],"issn-type":[{"value":"1198-743X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]}}}