{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:18:07Z","timestamp":1790050687773,"version":"4.0.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"crossref","award":["PICT 2008 n 0052"],"award-info":[{"award-number":["PICT 2008 n 0052"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Agencia Nacional de Promocion Cientifica y Tecnologica","award":["PICT 2012 n 0291"],"award-info":[{"award-number":["PICT 2012 n 0291"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Microbiology and Infection"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1111\/1469-0691.12631","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T06:19:06Z","timestamp":1395728346000},"page":"O861-O869","source":"Crossref","is-referenced-by-count":13,"title":["Epstein\u2013Barr virus BZLF1 gene polymorphisms: malignancy related or geographically distributed variants?"],"prefix":"10.1016","volume":"20","author":[{"given":"M.A.","family":"Lorenzetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gantuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Altcheh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"De Matteo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.A.","family":"Chabay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.V.","family":"Preciado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/1469-0691.12631_bib1","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1056\/NEJMcp1001116","article-title":"Infectious mononucleosis","volume":"362","author":"Luzuriaga","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1111\/1469-0691.12631_bib2","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nrc1452","article-title":"Epstein\u2013Barr virus: 40\u00a0years on","volume":"4","author":"Young","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"10.1111\/1469-0691.12631_bib3","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.virusres.2009.07.005","article-title":"The extent of genetic diversity of Epstein\u2013Barr virus and its geographic and disease patterns: a need for reappraisal","volume":"143","author":"Chang","year":"2009","journal-title":"Virus Res"},{"key":"10.1111\/1469-0691.12631_bib4","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3390\/pathogens1020156","article-title":"Epstein\u2013Barr virus sequence variation \u2013 biology and disease","volume":"1","author":"Tzellos","year":"2012","journal-title":"Pathogens"},{"key":"10.1111\/1469-0691.12631_bib5","doi-asserted-by":"crossref","first-page":"7836","DOI":"10.1128\/JVI.01197-10","article-title":"Transforming growth factor \u03b2\u03b2\u2010induced reactivation of Epstein\u2013Barr virus involves multiple SMAD\u2010binding elements cooperatively activating expression of the latent\u2010lytic switch BZLF1 gene","volume":"85","author":"Iempridee","year":"2011","journal-title":"J Virol"},{"key":"10.1111\/1469-0691.12631_bib6","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1099\/vir.0.017277-0","article-title":"Regulation of the Epstein\u2013Barr virus zp promoter in B lymphocytes during reactivation from latency","volume":"91","author":"McDonald","year":"2010","journal-title":"J Gen Virol"},{"key":"10.1111\/1469-0691.12631_bib7","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1128\/JVI.01995-12","article-title":"Essential role of RTA in lytic DNA replication of Epstein\u2013Barr virus","volume":"87","author":"El\u2010Guindy","year":"2013","journal-title":"J Virol"},{"key":"10.1111\/1469-0691.12631_bib8","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.micinf.2011.04.002","article-title":"Sequence variation of Epstein\u2013Barr virus (Ebv) BZLF1 gene in EBV\u2010associated gastric carcinomas and nasopharyngeal carcinomas in northern China","volume":"13","author":"Luo","year":"2011","journal-title":"Microbes Infect"},{"key":"10.1111\/1469-0691.12631_bib9","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1007\/s00705-008-0195-6","article-title":"New BZLF1 sequence variations in EBV\u2010associated undifferentiated nasopharyngeal carcinoma in southern China","volume":"153","author":"Ji","year":"2008","journal-title":"Arch Virol"},{"key":"10.1111\/1469-0691.12631_bib10","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0168-1702(01)00376-8","article-title":"Tissue specific distribution of Epstein\u2013Barr virus (EBV) BZLF1 gene variants in nasopharyngeal carcinoma (NPC) bearing patients","volume":"81","author":"Sacaze","year":"2001","journal-title":"Virus Res"},{"key":"10.1111\/1469-0691.12631_bib11","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1002\/jmv.21616","article-title":"Epstein\u2013Barr virus BZLF1 gene promoter variants in pediatric patients with acute infectious mononucleosis: its comparison with pediatric lymphomas","volume":"81","author":"Lorenzetti","year":"2009","journal-title":"J Med Virol"},{"key":"10.1111\/1469-0691.12631_bib12","first-page":"95","article-title":"Bioedit: a user friendly biological sequence alignment editor and analysis program for Windows 95\/98\/nt","volume":"41","author":"Hall","year":"1999","journal-title":"Nucleic Acids Symp Ser"},{"key":"10.1111\/1469-0691.12631_bib13","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1093\/molbev\/msr121","article-title":"Mega5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods","volume":"28","author":"Tamura","year":"2011","journal-title":"Mol Biol Evol"},{"key":"10.1111\/1469-0691.12631_bib14","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.meegid.2007.08.001","article-title":"Correlating viral phenotypes with phylogeny: accounting for phylogenetic uncertainty","volume":"8","author":"Parker","year":"2008","journal-title":"Infect Genet Evol"},{"key":"10.1111\/1469-0691.12631_bib15","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/1471-2148-7-214","article-title":"BEAST: Bayesian evolutionary analysis by sampling trees","volume":"7","author":"Drummond","year":"2007","journal-title":"BMC Evol Biol"},{"key":"10.1111\/1469-0691.12631_bib16","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/jmv.23715","article-title":"Epstein\u2013Barr virus diversity in immunocompetent healthy persons: reassessment of the distribution of genetic variants","volume":"86","author":"Ikeda","year":"2013","journal-title":"J Med Virol"},{"key":"10.1111\/1469-0691.12631_bib17","doi-asserted-by":"crossref","first-page":"7301","DOI":"10.1128\/JVI.70.10.7301-7305.1996","article-title":"Tissue distribution of Epstein\u2013Barr virus genotypes","volume":"70","author":"Chen","year":"1996","journal-title":"J Virol"},{"key":"10.1111\/1469-0691.12631_bib18","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1093\/jnci\/94.23.1757","article-title":"Discrete alterations in the BZLF1 promoter in tumor and non\u2010tumor\u2010associated Epstein\u2013Barr virus","volume":"94","author":"Guti\u00e9rrez","year":"2002","journal-title":"J Natl Cancer Inst"},{"key":"10.1111\/1469-0691.12631_bib19","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1093\/jnci\/95.13.1008","article-title":"Re: discrete alterations in the BZLF1 promoter in tumor and non\u2010tumor\u2010associated Epstein\u2013Barr virus","volume":"95","author":"Tong","year":"2003","journal-title":"J Natl Cancer Inst"},{"key":"10.1111\/1469-0691.12631_bib20","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jinf.2006.04.015","article-title":"Characterization of variants in the promoter of EBV gene BZLF1 in normal donors, HIV\u2010positive patients and in AIDS\u2010related lymphomas","volume":"54","author":"Martini","year":"2007","journal-title":"J Infect"},{"key":"10.1111\/1469-0691.12631_bib21","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/1743-422X-7-92","article-title":"Characterization of variants in the promoter of BZLF1 gene of EBV in nonmalignant EBV\u2010associated diseases in Chinese children","volume":"7","author":"Jin","year":"2010","journal-title":"Virol J"},{"key":"10.1111\/1469-0691.12631_bib22","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1002\/jmv.21871","article-title":"EBNA1 sequences in Argentinean pediatric acute and latent Epstein\u2013Barr virus infection reflect circulation of novel South American variants","volume":"82","author":"Lorenzetti","year":"2010","journal-title":"J Med Virol"},{"key":"10.1111\/1469-0691.12631_bib23","doi-asserted-by":"crossref","first-page":"9115","DOI":"10.1128\/JVI.00909-06","article-title":"Amino acids in the basic domain of Epstein\u2013Barr virus zebra protein play distinct roles in DNA binding, activation of early lytic gene expression, and promotion of viral DNA replication","volume":"80","author":"Heston","year":"2006","journal-title":"J Virol"},{"key":"10.1111\/1469-0691.12631_bib24","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1128\/JVI.01790-12","article-title":"Viral genome methylation differentially affects the ability of BZLF1 versus BRLF1 to activate Epstein\u2013Barr virus lytic gene expression and viral replication","volume":"87","author":"Wille","year":"2013","journal-title":"J Virol"},{"key":"10.1111\/1469-0691.12631_bib25","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.1128\/JVI.75.11.5381-5384.2001","article-title":"Biophysical analysis of natural variants of the multimerization region of Epstein\u2013Barr virus lytic\u2010switch protein BZLF1","volume":"75","author":"Hicks","year":"2001","journal-title":"J Virol"},{"key":"10.1111\/1469-0691.12631_bib26","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1128\/JVI.02500-08","article-title":"Interaction of Epstein\u2013Barr virus BZLF1 c\u2010terminal tail structure and core zipper is required for DNA replication but not for promoter transactivation","volume":"83","author":"McDonald","year":"2009","journal-title":"J Virol"},{"key":"10.1111\/1469-0691.12631_bib27","doi-asserted-by":"crossref","first-page":"8086","DOI":"10.1128\/JVI.00234-12","article-title":"Shutoff of BZLF1 gene expression is necessary for immortalization of primary B cells by Epstein\u2013Barr virus","volume":"86","author":"Yu","year":"2012","journal-title":"J Virol"},{"key":"10.1111\/1469-0691.12631_bib28","doi-asserted-by":"crossref","first-page":"7976","DOI":"10.1128\/JVI.00770-12","article-title":"An Epstein\u2013Barr virus (EBV) mutant with enhanced BZLF1 expression causes lymphomas with abortive lytic EBV infection in a humanized mouse model","volume":"86","author":"Ma","year":"2012","journal-title":"J Virol"},{"key":"10.1111\/1469-0691.12631_bib29","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1158\/1078-0432.CCR-06-2295","article-title":"Virus\u2010associated tumor imaging by induction of viral gene expression","volume":"13","author":"Fu","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.1111\/1469-0691.12631_bib30","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/nm.1864","article-title":"Bortezomib\u2010induced enzyme\u2010targeted radiation therapy in herpesvirus\u2010associated tumors","volume":"14","author":"Fu","year":"2008","journal-title":"Nat Med"},{"key":"10.1111\/1469-0691.12631_bib31","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1086\/380800","article-title":"Biology of Epstein\u2013Barr virus during infectious mononucleosis","volume":"189","author":"Sitki\u2010Green","year":"2004","journal-title":"J Infect Dis"}],"container-title":["Clinical Microbiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X14653404?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X14653404?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T15:46:47Z","timestamp":1597592807000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1198743X14653404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S1198743X14653404"],"URL":"https:\/\/doi.org\/10.1111\/1469-0691.12631","relation":{},"ISSN":["1198-743X"],"issn-type":[{"value":"1198-743X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]}}}