{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:25:02Z","timestamp":1791354302674,"version":"4.3.1"},"reference-count":14,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000403","name":"Meningitis Research Foundation","doi-asserted-by":"publisher","award":["4\/00"],"award-info":[{"award-number":["4\/00"]}],"id":[{"id":"10.13039\/501100000403","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Microbiology and Infection"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1111\/1469-0691.12745","type":"journal-article","created":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T01:43:50Z","timestamp":1404179030000},"page":"1337-1342","source":"Crossref","is-referenced-by-count":13,"title":["MBL2 deficiency is associated with higher genomic bacterial loads during meningococcemia in young children"],"prefix":"10.1016","volume":"20","author":[{"given":"T.C.","family":"Darton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.L.","family":"Jack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Borrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Guiver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.B.","family":"Kaczmarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.W.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.J.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.C.","family":"Read","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/1469-0691.12745_bib1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1399-0039.2006.00649.x","article-title":"Mannose\u2010binding lectin in innate immunity: past, present and future","volume":"68","author":"Dommett","year":"2006","journal-title":"Tissue Antigens"},{"key":"10.1111\/1469-0691.12745_bib2","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S0140-6736(98)08350-0","article-title":"Association of variants of the gene for mannose\u2010binding lectin with susceptibility to meningococcal disease","volume":"353","author":"Hibberd","year":"1999","journal-title":"Lancet"},{"key":"10.1111\/1469-0691.12745_bib3","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/S0140-6736(99)02563-5","article-title":"Association of familial deficiency of mannose\u2010binding lectin and meningococcal disease","volume":"354","author":"Bax","year":"1999","journal-title":"Lancet"},{"key":"10.1111\/1469-0691.12745_bib4","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/01.inf.0000256751.76218.7c","article-title":"Age\u2010dependent association of human mannose\u2010binding lectin mutations with susceptibility to invasive meningococcal disease in childhood","volume":"26","author":"Faber","year":"2007","journal-title":"Pediatr Infect Dis J"},{"key":"10.1111\/1469-0691.12745_bib5","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1744-313X.2012.01095.x","article-title":"Genetic susceptibility to invasive meningococcal disease: MBL2 structural polymorphisms revisited in a large case\u2013control study and a systematic review","volume":"39","author":"Bradley","year":"2012","journal-title":"Int J Immunogenet"},{"key":"10.1111\/1469-0691.12745_bib6","doi-asserted-by":"crossref","first-page":"625803","DOI":"10.1155\/2013\/625803","article-title":"The Role of Mannose\u2010Binding Lectin in Severe Sepsis and Septic Shock","volume":"2013","author":"De Pascale","year":"2013","journal-title":"Mediators Inflamm"},{"key":"10.1111\/1469-0691.12745_bib7","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1016\/j.molimm.2009.05.005","article-title":"MBL2, FCN1, FCN2 and FCN3\u2010The genes behind the initiation of the lectin pathway of complement","volume":"46","author":"Garred","year":"2009","journal-title":"Mol Immunol"},{"key":"10.1111\/1469-0691.12745_bib8","first-page":"305","article-title":"Mannose\u2010binding lectin: structure, function, genetics and disease associations","volume":"2","author":"Turner","year":"2000","journal-title":"Rev Immunogenet"},{"key":"10.1111\/1469-0691.12745_bib9","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1086\/596707","article-title":"Severity of meningococcal disease associated with genomic bacterial load","volume":"48","author":"Darton","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.1111\/1469-0691.12745_bib10","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1128\/JCM.39.4.1553-1558.2001","article-title":"Simultaneous detection of Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae in suspected cases of meningitis and septicemia using real\u2010time PCR","volume":"39","author":"Corless","year":"2001","journal-title":"J Clin Microbiol"},{"key":"10.1111\/1469-0691.12745_bib11","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1093\/hmg\/9.10.1481","article-title":"Restricted polymorphism of the mannose\u2010binding lectin gene of indigenous Australians","volume":"9","author":"Turner","year":"2000","journal-title":"Hum Mol Genet"},{"key":"10.1111\/1469-0691.12745_bib12","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cyto.2004.06.007","article-title":"Mannose binding lectin enhances IL\u20101beta and IL\u201010 induction by non\u2010lipopolysaccharide (LPS) components of Neisseria meningitidis","volume":"28","author":"Sprong","year":"2004","journal-title":"Cytokine"},{"key":"10.1111\/1469-0691.12745_bib13","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1189\/jlb.0604342","article-title":"Mannose\u2010binding lectin enhances phagocytosis and killing of Neisseria meningitidis by human macrophages","volume":"77","author":"Jack","year":"2005","journal-title":"J Leukoc Biol"},{"key":"10.1111\/1469-0691.12745_bib14","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jaci.2008.05.025","article-title":"An age\u2010dependent association of mannose\u2010binding lectin\u20102 genetic variants on HIV\u20101\u2010related disease in children","volume":"122","author":"Singh","year":"2008","journal-title":"J Allergy Clin Immunol"}],"container-title":["Clinical Microbiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X15600386?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X15600386?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T08:54:35Z","timestamp":1538470475000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1198743X15600386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":14,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S1198743X15600386"],"URL":"https:\/\/doi.org\/10.1111\/1469-0691.12745","relation":{},"ISSN":["1198-743X"],"issn-type":[{"value":"1198-743X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]}}}